Patients with rheumatoid arthritis and osteoarthritis in terms of sex hormone receptors and histopathological comparison of features

Özet

Objectives: This study aims to investigate the relationship between estrogen receptors (ERs) and progesterone receptors (PRs) and histopathologicalfindings in synovial tissue in rheumatoid arthritis (RA) and osteoarthritis (OA) patients.Patients and methods: Synovial tissue samples obtained from synovial surgery from 30 RA (10 males, 20 females) and 92 OA (27 males, 65 females)patients with median age of 59 (range, 50 to 67) years were analyzed retrospectively between January 2010 and January 2019. The relationshipbetween histopathological features and hormone receptor presence was analyzed.Results: There was a meaningful relationship between histopathological parameters and RA and OA (p=0.01). The sex hormone receptor'spresence was significantly higher in females with RA (p=0.01). Additionally, in the RA group, there was a remarkable relationship between ER andfocal aggregates of lymphocytes (p=0.01), perivascular infiltrates of lymphocytes (p=0.03), and diffuse infiltrates of lymphocytes (p=0.01). In theOA group, a significant relationship was observed between PR and subchondral inflammation (p=0.01). In multivariate analysis, it was observed thatER was an independent risk factor for focal aggregates of lymphocytes in RA group (odds ratio [OR]=1.51 [1.02-2.25], p=0.04). Besides, PR was foundto be an independent risk factor for subchondral inflammation in OA group (OR=3.90 [1.28-11.80], p=0.02).Conclusion: The presence of the sex hormone receptor in the synovium may change histopathological features and affect the clinical course.