Factors predicting recurrence in non-muscle invasive bladder cancers

Özet

Aims: We aimed to assess patients with non-muscle invasive bladder cancer (NMIBC) to findout the factors affecting recurrence after initial treatment.Methods: In this retrospective cohort study, we investigated patients who underwenttransurethral bladder tumor resection (TURB) between January 2014 and April 2020. Patients’age, gender, initial symptoms, time from the initial symptoms to hospital admission, historyof systemic diseases, smoking history, pathological features, intra-vesical treatment recordsand information about recurrence were recorded. Recurrence was considered as any tumordevelopment other than the aforementioned residual tumor.Results: A total of 103 patients (mean±SD age: 68.5±9.1 years; 93 men and 10 women) wereevaluated. The mean diameter of the tumors was 3±1.6 cm. Following the initial TURB and/or re-TURB, 28 (27.1%) patients underwent induction chemotherapy or BCG therapy. Residualtumor was detected in 35 (34%) patients who were either detected within the first three monthsfollowing the TURB, without receiving any intravesical therapy, or in re-TURB performed forthe purpose of resection of the residual visible bulky lesions following an incomplete initialresection. Eleven patients (10.6%) recurred within a median of 18 months of follow-up. Themedian recurrence-free survival was 25 months (95% confidence interval (CI): 16.5-33.4). Thepresence of carcinoma in situ (CIS) [Hazard ratio (HR): 3.00, 95% CI: 1.2-7.6, p=0.03], femalegender (HR: 2.38, 95% CI: 1.03-5.4, p=0.03) and age >70 years (HR: 1.87, 95% CI: 1.02-3.41,p=0.03) were significantly associated with recurrence.Conclusions: The present study showed that the presence of CIS, female gender, and age >70years were independently associated with the recurrence of NMIBC.