Dergiler / Uluslararası Hematoloji-Onkoloji Dergisi / 2018 / Cilt: 28 - Sayı: 2
High Metabolic Tumor Volume and Total Lesion Glycolysis Derived from Baseline 18F-FDG PET/CT may Predict the Metabolic Abnormalities in Newly Diagnosed Cancer Patients
- Sayfa
- 69–78
- DOI
- —
Özet
The present study was conducted to investigate the role of total body Metabolic Tumor Volume (MTV, mm3) and Total Lesion Glyco-lysis (TLG) values obtained by PET/CT imaging for predicting metabolic abnormalities in newly diagnosed cancer patients. Patients having solid tumors with initial PET/CT staging were evaluated in a prospective cohort study. MTV and TLG values of all patients were measured besides SUV values as PET/CT parameters. Initial metabolic status of patients was evaluated based on basal metabolic rates, serum vitamin, mineral, and biochemical metabolite levels and antioxidant enzyme capacities. The MTV and TLG levels revealed significant relationships with cancer-induced metabolic abnormalities as high BMR and LDH, and low albumin levels as well as ad-vanced stage and presence of metastasis (p 20 Kcal/kg) were obtained to be > 52400 mm3 for MTV (0.84 and 0.63) and >274208 for TLG (0.84 and 0.63). The same values for high LDH were ≥ 219520 mm3 (0.52 and 0.88) for MTV and ≥ 411792 (0.78 and 0.58) for TLG, respectively. The values for low albumin levels were ≥89520 mm3 (0.63 and 0.10) for MTV, and ≥ 887840 (0.75 and 1.00 ) for TLG, respectively. In conclusion, MTV and TLG cut-off values determined by ROC analysis can predict metabolic abnormalities in initial BMR, LDH and albumin levels with high specificity and sensitivity. It is recommended to test MTV and TLG levels to determine initial metabolic status of diverse patient groups with various types of cancer.
Abstract
Bu çalışma PET/CT’den elde edilen tüm vücut Metabolik Tümör Volümü (MTV, mm3) ve Toplam Lezyon Glikoliz (TLG) değerlerinin kans-er hastalarında metabolik bozuklukları tahmin etmedeki rolünü araştırmak için yapıldı. Prospektif kohort çalışmada başlangıç PET/CT evrelemesi yapılan yeni tanı konmuş solid tümör hastaları değerlendirildi. Tüm hastalarda PET/CT parametresi olarak SUV değerlerinin yanında MTV ve TLG değerleri de ölçüldü. Hastaların başlangıç metabolik durumu bazal metabolizma hızları, serum vitamin, mineral ve biyokimyasal metabolit düzeyleri ve antioksidan enzim kapasiteleri ile değerlendirildi. MTV ve TLG değerleri ileri evre hastalık ve metastaz varlığının yanı sıra artmış BMR, yüksek LDH ve düşük albümin değerleri gibi kanserin yol açtığı metabolik bozukluklar ile anlamlı ilişki gösterdi (p< 0.05).