Dergiler / Selçuk Tıp Dergisi / 2001 / Cilt: 17 - Sayı: 3
Böbrek proksimal tübülusuna deneysel hipotiroidizimin etkileri
- Dergi
- Selçuk Tıp Dergisi
- Sayfa
- 165–169
- DOI
- —
Özet
Bu çalismada 6-propil-2-tiourasil (PTU) ile siçanlarda deneysel hipotiroidizm olusturularak böbrekteki etkileri, glomerül ve tübül yapilari mikroskopik düzeyde incelenmesi amaçlandi. Agirliklari ortalama 200-250 gr olan 60 günlük toplam 12 ergin disi siçanlar kullanildi. Denekler 2 gruba ayrilarak bir gruba 15 gün süre ile 10 mg/kg gün propil tiourasil periton içine verildi. Kontrol olarak kullanilan diger gruptaki deneklere serum fizyolojik enjekte edildi. Isik ve elektron mikroskopik olarak incelenen böbrek yapisinda iç ve dis medullanin kontrol grubuna benzedigi, kortekste bazi glomerül kapillerlerinde genisleme, dolgunluk, kapsül boslugunda genisleme oldugu görüldü. Özellikle proksimal tübüllerde bazal katlantilarin oldukça belirginlestigi, epitel hücreleri arasinda açilmalar oldugu, vakuolize bir görünüm olustugu saptandi. Ince yapi düzeyinde glomerül filtrasyon bariyerinde herhangi bir bozulma veya bazal laminada degisiklik olmadigi, kontrol grubu ile benzerlik gösterdigi tespit edildi.
Abstract
In this study, experimental hypothyroidism in rats was induced using 6-propyl-2-tiouracyl (PTU) and its effects on kidney, glomerule and tubules structure were investigated at microscopic level. In the experiments, 60 days old 12 female rats which weighted 200-250 gr were used. The rats were separeted into two groups. To one group, 10 mg/kg day PTU was introduced intraperitoneally for 15 days. To other group which was used as a control group %0.9 physiological solution (PS) was injected intraperitoneally for 15 days.. In the renal structure investigated by light and electron microscope, it was observed that internal and external medulla were similar to those of the control group. Moreover, some expansion in glomerul capillaries of cortex, plumpness and expansion in capsule cavity were observed. Particularly, basal folding in proximal tubule was found to be evident. Likewise, increase in intercelluler spaces and formation of a vacuolize view were found. It was found that there was no any damage in glomerule filtration barrier at thin structure level. It was also found that there not no any difference in basal lamina which was similar to the control group.