Dergiler / EurAsian Journal of BioSciences (elektronik) / 2009 / Sayı: 3
The effect of regular intake of Terminalia chebul on oxidative stress in mice originated from Salmonella typhimurium
- Sayı
- 2009 · Sayı: 3
- Sayfa
- 113–121
- DOI
- —
Özet
Tifo endemiktir ve gelismekte olan ülkelerin cogunda bir halk sagligi problemi olmaya devam etmektedir. Antibiyotiklere karsi artan direnc ve asinin sinirli kullanimi sebebiyle, bu hastaligin tedavisinde dogal bitki ürünlerinden faydalanma yollarini arastirmak bir gereklilik haline gelmistir. Bu calismada, Isvicre albino farelerinde Salmonella typhimurium tarafindan olusturulan oksidatif stresin giderilmesiyle ilgili olarak, Terminalia chebula'nin sivi ozütleri incelenmistir. 30 gün boyunca, vücut agirligina gore 500 mg/kg (T500) dozda T. chebula su ozütü ile agiz yoluyla on muamele edilen fareler, enfekte tuzla muamele edilen kontrollere oranla, ksantin oksidaz aktivitesinde %31 oraninda azalma, glutanin peroksidaz ve glutanin redüktaz aktivitesinde %25'lik bir artis gosterdi. Oksidatif stresteki azalma, S. typhimurium'a karsi ilacin etkinligini gostermektedir. Bu ilac tifoya karsi da kullanilabilir.
Abstract
Typhoid is endemic and in most developing countries remains a public health problem. Due to an increasing resistance to antibiotics and the limited scope of the vaccine the requirement is to explore the efficacy of natural plant products in the treatment of this disease. In this study we have evaluated the aqueous extract of Terminalia chebula in connection with the oxidative stress generated in Swiss albino mice by Salmonella typhimurium. Mice pretreated through the oral route with the water extract of T. chebula at a dose of 500 mg/kg (T500) body wt for a period of 30 d exhibited a full protection against 1X105 Colony forming units (CFU) of S. typhimurium injected intraperitonially. Mice pretreated with T500 for a period of 30 d followed with 50000 CFU of S. typhimurium showed a decrease in Xanthine oxidase activity by 31% and an increase in both glutathione peroxidase and glutathione reductase activity by 25% as compared to the infected saline treated control. The reduction in the oxidative stress indicated the effectiveness of the drug against S. typhimurium which can also be used against typhoid.