Brain FDG-PET Scan and Brain Perfusion SPECT in the Diagnosis of Neuroacanthocytosis Syndromes

Nöroakantositoz Sendromlarının Tanısında Beyin FGD-PET Görüntüleme ve Beyin Perfüzyon SPECT

Özet

Nöroakontozis sendromları (NA) koreik hareket bozukluğu, psikiyatrik bulgular ve kognitif düşüş ve miyopati ve aksonal nöropatiyi içine alan ilave çoklu sistem tutulumundan oluşan otozomal resesif kore-akantozis ve X-linked McLeod sendromundan oluşur. Fluor 18-2-fluoro-2-deoxyglucose (18F-FDG) pozitron emisyon tomografi (PET) ve technetium 99m -d, l-hexamethyl-propylene amine oxime (99mTc-HMPAO) beyin single photon emission computed tomography (SPECT) demans, epilepsi ve hareket hastalıkları gibi nörolojik hastalıkların saptanmasında artan şekilde kullanılmaktadır. Bu olgu sunumunda, biz beyin metabolizma PET ve beyin perfüzyon SPECT görüntüleme bulguları olan nöroakantozisli iki hastayı rapor ediyoruz. Ek olarak nöroakantozis sendromlu hastalardaki beyin PET ve beyin SPECT bulguları gözden geçirildi

Abstract

Neuroacanthocytosis syndromes (NA) include autosomal recessive chorea-acanthocytosis and X-linked McLeod syndrome consisting of a choreatic movement disorder, psychiatric manifestations and cognitive decline, and additional multi-system features including myopathy and axonal neuropathy. Fluor 18 -2-fluoro-2-deoxyglucose (18F-FDG-PET) positron emission tomography (PET) and technetium 99m -d, l-hexamethyl-propylene amine oxime (99mTc-HMPAO) brain single photon emission computed tomography (SPECT) have been increasingly used for the detection of neurologic disorders, such as dementia, epilepsy, and movement disorders. In this case report, we report two patients with neuroacanthocytosis syndromes with the imaging features of brain metabolism by PET and brain perfusion by SPECT. Brain PET and brain SPECT findings of patients with neuroacanthocytosis syndromes were also reviewed