Oxidation of some benzyl substitutedfused quinazoline derivatives

Özet

In this study, syntheses of some benzoyl substituted fused quinazoline derivatives 4a-d, using Fieser’s reagent, are reported. An unexpected product 5a and6 were isolated from the reaction mixture. Based on the experimental data, a possible oxidation mechanism of ketone 4awith chromium trioxide is described. The synthesized compounds were characterized by 1H, 13C, 19F NMR and LC-MSdata.