A study of Minisci reaction by changing Fe2+equivalency: Preparation of arylpyridinyl methanol

Özet

We aimed the synthesis of carboxamide 8 and10, however, beside the main product, one more species was detected in the reaction solution. The characterization of this side product showed that it was the other isomer of the main product. To establish reaction conditions for the synthesis of carboxamide derivatives, we have set upseveralexperiments by changing the Fe2+stoichiometry. When a molarequivalent Fe2+was used, only tworeaction products8 and 10wereobtained. The increase in Fe2+stoichiometry caused the formation of side product 9 and 11 even formation of reduced alcohol products (12-15) by Minisci reaction.