Low IgA associated with short arm deletion of chromosome 18

Abstract

A one-year-old boy with the short arm deletion of chromosome 18 is reported. The case has IgA deficiency and facial dysmorphism. Chromosome analysis showed that his father had 32% premature centromere division (PCD). The deletion of short arm of chromosome 18 in our case may have occurred because of PCD in the father. Our case might be an important example for concurrent appearance of these chromosomal abnormalities.