Dergiler / Marmara Medical Journal / 2008 / Cilt: 21 - Sayı: 2
The efficacy of trospium chloride in overactive bladder
- Sayfa
- 127–132
- DOI
- —
Özet
Amaç: Aşırı aktif mesane sendromu bulunan kadınlarda trospium tedavisinin etkinliği ve bu etkinin ürodinamik bulgular ile ilişkisi araştırıldı. Materyal Metod: Aşırı aktif mesane sendromu bulunan 44 kadın hasta çalışmaya alındı. 8 haftalık trospiyum tedavisinden sonra, hastaların tedavi öncesi ve sonrası OAB-V8 semptom skoru, ürodinamik bulguları karşılaştırıldı. Bulgular: Ortalama OAB-V8 semptom skoru tedavi ile birlikte anlamlı olarak düşük bulundu (11.9+6.3; 24.9+5.1; p<0.05).Detrusor aşırı aktivitesi bulunan kadın hastaların (10.3+4.1) detrusor aşırı aktivitesi olmayan kadın hastalara (14.2+5.3) göre trospium tedavisinden daha fazla fayda gördükleri saptandı. Sonuç: Trospium tedavisi ispatlanmış detrusor aşırı aktivitesi olan kadın hastalarda daha etkili bulunmuştur.
Abstract
Objective: The efficacy of trospium chloride on the lower urinary tract symptoms and urodynamic parameters in women with OAB were investigated. Material and Methods: 44 consecutive women with OAB were enrolled in this study. Before and after 8 weeks of TC treatment, OAB-V8 scores of the patients related to the current symptoms were collected. Urodynamic studies were performed in 28 patients (63.6%). Primary and outcome variables were OAB symptom score and urodynamic findings. The difference in response to TC according to the lower urinary tract symptoms between the patients with or without proven detrusor overactivity was analyzed. Results: Mean OAB-V8 score of the patients after the treatment with TC was significantly lower than before the treatment (11.9+6.3; 24.9+5.1; p<0.05). After treatment, when compared to the mean OAB-V8 score of patients without DO (14.2+5.3), mean symptom score of those with proven DO (10.3+4.1) was found to be statistically lower (p<0.05). Conclusion: Trospium was much more effective in women with proven DO than without DO to improve symptoms.