Effects of significant weight loss following bariatric surgery on red cell distribution width and mean platelet volume

Özet

Aim: Elevated red blood cell distribution width (RDW) and mean platelet volume (MPV) levels which are closely associated with chronic inflammation and platelet aggregation are suggested as independent predictors of obesity and cardiovascular diseases. However influence of significant weight loss following bariatric surgery on these parameters is unknown. Therefore we aimed to find out the effect of significant weight loss following laparosco-pic sleeve gastrectomy (LSG) on RDW and MPV levels.Methods: The medical data of 98 morbid obese subjects (25 male, 73 female) who were operated between February 2015 and June 2017 according to indications of bariatric surgery in current guide-lines including body mass index (BMI) >40 kg/m2 or BMI= 35-40 kg/m2 with additional comorbidities were recorded. The difference bet-ween baseline and values at one year was expressed as a delta (Δ).Results: The mean age of our study population was 41.89±11.99 years and mean weight loss in one year after LSG was 45.41±13.13 kg (36.5%). BMI decreased from 46.60±7.11 kg/m2 to 29.58±4.63 kg/m2. Compared to the baseline, significant decreases in RDW (14.61±1.69 % vs. 13.71±2.10 %; p<0.01) and MPV (8.63±1.45 vs. 7.92±1.24 fL, p<0.001) levels were found in the postoperative one-year values. In addition; ΔVKI was positively correlated with ΔRDW (r=0.343, p<0.01) and ΔMPV (r=0.322, p<0.01).Conclusion: We found that morbid obese subjects have signifi-cantly decreased RDW and MPV levels which are correlated to their weight loss in one-year follow-up after LSG. If we think that several factors may affect these parameters, conduction of further pros-pective large-scale studies are needed.