Superoxide dismutase and xanthine oxidase activities in New Zealand rabbits treated with different types of glycosaminoglycans (GAGs) after osteoarthritis surgery

Özet

Chondroitin sulphate is one of the glycosaminoglycans (GAGs) generally acquired from animal tissues. CS has an anti-inflammatory, anti-apoptotic and antioxidant properties. The GAGs have been recently reported to possess the ability to influence oxidative stress known to lead to free radical mediated biological damage. Herein, we report the effect of some GAGs on superoxide dismutase (SOD) and xanthine oxidase (XO) activities in experimental animal models submitted to osteoarthritis surgery. In this respect, SOD and XO activities were investigated in New Zealand rabbits treated with different types of glycosaminoglycans (GAGs); commercial chondroitin sulphate (CCS) and bacterial chondroitin sulphate (BCS) (produced by using E. coli). The results of this study revealed that both CS sources significantly (P <0.05) decreased the levels of SOD and XO activities in the animal models; however, this decrease was more prominent in the animals treated with BCS than in those treated with CCS in terms of SOD activity. Based on these results, it can be concluded that treatment of the animals with the bacterial chondroitin sulphate showed beneficial effects as revealed by oxidative models. This study confirms the antioxidant properties of GAGs, suggesting the hypothesis that chondroitin sulphate could function as a beneficial substance to control oxidative stress.