Inflammation, Left Ventricular Mass Index and Chronic Renal Failure in Diabetic Patients

Diyabetik Hastalarda Enflamasyon, Sol Ventrikül Kitle İndeksi ve Kronik Böbrek Yetmezliği

Egemen CEBECİ,Nilay Şengül SAMANCI,Sami UZUN,Serhat KARADAĞ,Meltem GÜRSU,Tuba Elif ŞENEL ÖZLER,Mustafa VELET,Savas OZTURK

Özet

Aim: The aim of this study was to determine the relationship between left ventricular hypertrophy (LVH) and inflammatory markers in patients with type 2 Diabetes Mellitus (T2DM) with diabetic nephropathy at different stages. Methods: Our study was a cross-sectional study involving patients with various stage of T2DM. Patients with LVH were identified by 2D echocardiography. Plasma human tumor necrosis factor alpha (TNF-α), interleukin (IL)-1, IL-6, vaspin, vispatin and midkine were measured. Results: A total of 59 T2DM patients (56% women) with a mean age of 56.1±8.8 years were included in the study. The mean left ventricular mass index was 129±30. LVH was detected in 62.7% of the patients. Patients with an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2 had a higher incidence of LVH than patients with an eGFR ≥60 mL/min/1.73 m2 (p=0.03). The TNF-α levels in patients with LVH with low eGFR was found to be statistically significantly higher than in patients without LVH (p=0.047). The level of vaspin was statistically significantly higher in patients with LVH (p=0.01). Conclusion: LVH was found to be more frequent in patients with low eGFR, and from inflammatory markers, it was found to be associated only with TNF-α and vaspin

Abstract

Amaç: Çalışmamızın amacı farklı evrelerdeki tip 2 Diabetes Mellitus (T2DM) hastalarında sol ventrikül hipertrofisi (SVH) ve enflamatuvar biyobelirteçlerin arasındaki ilişkiyi ortaya koymaktır. Yöntemler: Kesitsel çalışmamıza çeşitli evrelerdeki T2DM hastaları dahil edildi. SVH 2D ekokardiyografi cihazı ile değerlendirildi. Tümor necrosis factor alpha (TNF-α), interleukin (IL)-1, IL-6, vaspin, vispatin ve midkine serumda ölçüldü. Bulgular: Ortalama yaşı 56,1±8,8 yıl olan 59 T2DM hastası (%56’sı kadın) çalışmaya dahil edildi. Sol ventrikül kitle indeksi 129±30 idi. SVH’si hastaların %62,7’sinde saptandı. Tahmini glomerüler filtrasyon hızı (tGFH) <60 mL/dk/1,73 m2 olan hastalarda tGFH’ı ≥60 mL/dk/1.73 m2 olan hastalara göre SVH daha yüksek oranda saptandı (p=0.03). Düşük tGFH olan hastalarda SVH’ı olan hastalar SVH’ı olmayan hastalara göre TNF-α seviyesi istatistiksel olarak daha yüksek saptandı (p=0.047). Vaspin SVH’si olan hastalarda daha yüksekti (p=0.01). Sonuç: SVH düşük tGFH’li hastalarda daha sıktı ve enflamatuvar biyobelirteçlerden sadece TNF-α ve vaspin ile ilişkili bulundu.