Dergiler / Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2019 / Cilt: 9 - Sayı: 1
One-Pot Synthesis of Substituted Phthalazine-5,10-dione Derivatives in the Presence of Triflate Catalyst
- Sayfa
- 468–478
- DOI
- —
Özet
In this study, substituted 1H-pyrazolo[1,2-b]phthalazine-5,10-diones which are considered that may possess biological activity have been obtained via one-pot multi-component cyclocondensation reaction of phthalhydrazide, aromatic aldehydes and malononitrile catalyzed in the presence of Cu(OTf)2 in very good yields and short times. The structures of all these synthesized compounds (4a-f) have been determined and characterized by infrared, nuclear magnetic resonance, mass spectral data, and elemental analysis.
Abstract
In this study, substituted 1H-pyrazolo[1,2-b]phthalazine-5,10-diones which are considered that may possess biological activity have been obtained via one-pot multi-component cyclocondensation reaction of phthalhydrazide, aromatic aldehydes and malononitrile catalyzed in the presence of Cu(OTf)2 in very good yields and short times. The structures of all these synthesized compounds (4a-f) have been determined and characterized by infrared, nuclear magnetic resonance, mass spectral data, and elemental analysis.