Granulocytic sarcoma of the lower female genital tract in a patient with chronic myelogenous leukemia

İptisam İpek MÜDERRİS,Olgun KONTAŞ,Yılmaz ŞAHİN,Ali ÜNAL,Eray KARAHACIOĞLU,Demet AYATA

Özet

Kronik Myeloid Löseminin blastik fazında nadir görülen bir durum olan alt genital traktta granülositik sarkom vakası'., sunulmuştur. Vulvar ağrı, kaşıntı ve kitle şikayeti ile hastanemize başvuran 34 yaşındaki hastanın pelvik muayenesinde vulva, vajen ve servikovaginal junction da sarı yeşil renkte küçük kitleler tesbit edildi. Servikovajinal sitolojide myeloid prekürsör hücreler görüldü. Lezyonlardan alınan biyopsilerde granülositik sarkom tesbit edildi. Kemik iliği biyopsisinde Hijjersellüler elementlere rastlandı. Kronik myeloid löseminin blastik faz tanısı konarak cytarabin ve doxorubicin başlandı. Hasta tedavinin 12. gününde serebral kanamadan kaybedildi. Sonuç olarak lösemili hastalarda granülositik sarkom yönünden genital trakt taranmalıdır.

Abstract

Acase of granuiocytic sarcoma in a patient with chromic myeioidJeukemia at the blastic phase is reviewed with respect to clinical and pathological characteristics. A 34-year-old patient was admitted to hospital with vulvar pain, masses and itching. Pelvic examination was remarkable for multiple yellow-green colored small masses of the vulva, vagina, cervix and cervicovaginal junction. Cytology of cervicovaginal smear showed myeloid precursor celts. The biopsy of these lesions was diagnosed as granuiocytic sarcoma. Bone marrow aspiration showed hypercellular marrow elements, predominantly blasts (80%) and differentiated myeloid elements. Shjş was diagnosed ,as a blastic phase of chronic myelogenous leukemfa and chemotherapy consisting bfccytarabine and doxorubicine was begun. She died because of cerebral hemorrhage at the 12th day the therapy. In conlusion we suggest that the women with leukemia should be examined for granuiocytic sarcoma of the genital tract.