Dergiler / Glokom Katarakt / 2011 / Cilt: 6 - Sayı: 3
The effects of latanoprost on corneal thickness, endothelial cell density, topography; Anterior chamber depth and axial length
- Dergi
- Glokom Katarakt
- Sayfa
- 163–167
- DOI
- —
Özet
Amaç: Latanoprost siliyer cisimde ekstrasellüler matriks ve kollajen metabolizması üzerine etkilidir. Aynı mekanizma kornea, zonüller ve sklera için de geçerli olabilir. Çalışmanın amacı latanoprostun aksiyel uzunluk (AU), ön kamara derinliği (ÖKD), korneal topografi, endotel hücre yoğunluğu (EHY) ve merkezi kornea kalınlığı (MKK) üzerindeki etkilerini değerlendirmektir. Gereç ve Yöntem: Çalışmaya yeni tanı konmuş primer açık açılı, normotansif glokomlu veya oküler hipertansiyonlu 54 hastanın 54 gözü alındı. Hastalar, tedavi öncesi ve latanoprost tedavisi sonrası 1., 3. ve 6. ayda muayene edildi ve göz içi basınçları (GİB), AU, ÖKD, korneal topografi, EHY ve MKK’ları değerlendirildi. Bulgular: Yirmi bir erkek, 33 kadın hastanın ortalama yaşı 59.2±12.6 idi. GİB tedavi öncesi 21.4±7.2 mmHg iken tedavi sonrası 1. ayda 14.6±4.6, 3. ayda 14.9±3.6 ve 6. ayda 14.7±3.5 mmHg’ya düştü (p 0.05). MKK’nda istatistiksel olarak anlamlı incelme saptandı (p=0.03). Sonuç: Latanoprost %0.005, 6 aylık tedavi süresinde AU, ÖKD, EHY ve korneal topografi parametrelerinde klinik olrak tespit edilebilen değişikliğe neden olmazken MKK’nda anlamlı incelmeye yol açmaktadır. Latanoprostun öküler etkilerinin aydınlatılması için daha geniş-uzun takipli çalışmalara ihtiyaç vardır.
Abstract
Purpose: Latanoprost has effects on extracellular matrix and collagen metabolism in the ciliary body. The same mechanisms probably act in cornea, zonula fibers and sclera. The aim of the current study was to analyze the clinical visible effects latanoprost on axial length (AL), anterior chamber depth (ACD), corneal topography, endothelial cell density (ECD) and central corneal thickness (CCT). Materials and Methods: Fifty-four eyes of 54 patients with newly diagnosed primary open angle glaucoma, normotensive glaucoma or ocular hypertension were included. Patients were examined before treatment and at the first, third and sixth month after latanoprost treatment. Visual acuity (VA), spheric equıvalent (SE), intraocular pressure (IOP), AL, ACD, corneal topography, ECD, and CCT were measured at each examination. Results: Twenty-one males and 33 females with a mean age of 59.2±12.6 years were included in the study. The mean IOP which was 21.4±7.2 mmHg before therapy significantly decreased to 14.6±4.6 mmHg at the first month, 14.9±3.6 mmHg at the third month and 14.7±3.5 mmHg at the sixth month (p<0.001). A significant positive correlation was found between baseline IOP and IOP-lowering effect and a negative correlation was present between IOPlowering effect and AL (p<0.05). No significant change in VA and SE was found after treatment. No significant change was observed in AL, ACD, ECD, and corneal topography parameters (p>0.05). A statistically significant reduction in CCT was observed within 6 months (p=0.03). Conclusion: Although latanoprost 0.005% does not cause clinically detectable changes in corneal topography, ECD, ACD and AL, it only causes statistically significant reduction in central corneal thickness within 6 months of the treatment period. Further large-scale studies with longer follow-ups are needed to elucidate effects of latanoprost on ocular structures.