Dergiler / Turkish Journal of Medical Sciences / 2014 / Cilt: 44 - Sayı: 6
Investigation of linezolid resistance in Staphylococcus epidermidis: first reported linezolid resistant coagulase negative staphylococcus in Turkey
- Sayfa
- 1136–1138
- DOI
- —
Özet
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Abstract
position 2309. It is thought that linezolid binds to any location in the vicinity of the peptidyl transferase center (PTC) (4). The PTC is located in domain V of 23S rRNA, and this center plays a key role in peptide bond formation and peptide release (16). Although PTC is known as the primer binding site of the drug, it is controversial that different sites of ribosome can interact with linezolid. The A-site and P-site of large ribosomal units are among these interaction regions (17).Nucleotide A2309 is located in