Gestational Diabetes Mellitus and Iron Deficiency Anemia

Neslihan YEREBASMAZ,Şeyma ASİLTÜRK,Erdem FADILLIOĞLU,Özlem ŞENGÜL,Serdar YALVAÇ,Ömer KANDEMİR

Özet

AMAÇ: Erken gebelik döneminde var olan demir eksikliği anemisinin gestasyonel diabetes mellitus gelişimine etkisini araştırmak.GEREÇ VE YÖNTEM: Bu retrospektif kohort çalışmaya 24-28.gebelik haftaları arasında gestasyonel diabetes mellitus tanısıalmış 131 gebe (çalışma grubu) ve gestasyonel diyabet için tarama testi negatif olan 300 gebe (kontrol grubu) dahil edilmiştir. Her iki gruptaki gebelerin ilk trimester hemoglobin ve ortalama korpuskular hacim değerleri anemi yönünden değerlendirilmiştir. BULGULAR: Çalışmamızda ortalama hemoglobin değerleri veortalama korpuskular hacim gestasyonel diyabetli hasta grubunda anlamlı olarak daha fazla idi (sırasıyla 12,2±1,26 vs.11,72±1,17; p 4000 g yenidoğanlar anlamlı olarak daha fazlaydı(19,8% vs.6,7%) (p<0,001).SONUÇ: Gestasyonel diabetes mellitus gelişimi ilk trimesterdeölçülen yüksek hemoglobin değerleri ile ilgilidir.

Abstract

OBJECTIVE: To determine whether gestational diabetes mellitus is influenced by the presence of irondeficiency anemia in early pregnancy.STUDY DESIGN: This retrospective cohort study included 131 gestational diabetes mellitus and 300non-gestational diabetes mellitus pregnants that were screened and diagnosed between the 24-28 weekof gestation. Gestational diabetes mellitus was diagnosed by two-step testing regimen. Anemia in pregnancy was defined as hemoglobin below 11 g/dL in the first trimester. RESULTS: We found out that the mean hemoglobin value and mean corpuscular volume were significantly higher in the gestational diabetes mellitus group (12.2±1.26 vs. 11.72±1.17; p<0.001 and89.29±7.55 vs. 84.64±6.93; p<0.001). After the analysis of covariance for maternal age, body massindex, parity, birth weight there were significant differences in hemoglobin values and mean corpuscular volume values between two groups (respectively p=0.002, p<0.001). In the gestational diabetes mellitus group >4000 g newborns were significantly higher (19.8% vs.6.7%) (p<0.001).CONCLUSION: We demonstrated that gestational diabetes mellitus was associated with high levels ofhemoglobin that was measured in first trimester