Dergiler / Turkish Journal of Chemistry / 2012 / Cilt: 36 - Sayı: 5
Chemical and biotransformation of Gelomulide F: a rare diterpene lactone
- Sayfa
- 759–763
- DOI
- —
Özet
Chemical and biotransformations of a rare diterpene lactone, Gelomulide F (1), from the cytotoxic extract of leaves of Suregada multiflora were studied. Fermentation of compound 1 with Sachromyces cerevisiae transformed it to Gelomulide D (2) and E (3), whereas its treatment with 2N KOH yielded Gelomulide D (2). In addition, a novel compound (4) was obtained by its diastereo and chemoselective reduction with NaBH4. All of these compounds were characterized on the basis of extensive 1H-NMR, 13C-NMR, 2D NMR, and mass spectral analyses.
Abstract
Chemical and biotransformations of a rare diterpene lactone, Gelomulide F (1), from the cytotoxic extract of leaves of Suregada multiflora were studied. Fermentation of compound 1 with Sachromyces cerevisiae transformed it to Gelomulide D (2) and E (3), whereas its treatment with 2N KOH yielded Gelomulide D (2). In addition, a novel compound (4) was obtained by its diastereo and chemoselective reduction with NaBH4. All of these compounds were characterized on the basis of extensive 1H-NMR, 13C-NMR, 2D NMR, and mass spectral analyses.