Investigation of Possible Antidiabetic Effects of Potentilla Fulgens in Diabetic Rats and Comparison with Other Antidiabetics

Özet

Introduction: The current antidiabetic drugs have adverse side effects and the effects may decrease overtime depending on continuous use. In recent years, phytochemicals of natural plant origin, which show antidiabetic properties and have fewer side effects, have been the subject of research. However, studies and clinical studies on the antidiabetic and hypoglycemic effects of Potentilla fulgens are still not enough. We aimed to examine the antidiabetic effects of P. fulgens in diabetic rats and to contribute to new treatment approaches by comparing them with other antidiabetics. Methods: In this study, rats were divided into seven groups, one control and six diabetic groups as seven rats in each group. The rats in which diabetes was induced by streptozotocin were sacrificed after treatment with two different doses of intraperitoneal and intragastric P. fulgens and standard antidiabetic drugs, metformin and gliclazide for 3 weeks. Results: Intraperitoneal administration of P. fulgens significantly improved the activity of liver enzymes related to fasting blood glucose levels and carbohydrate metabolism. Intragastric 450 mg/kg/day P. fulgens did not show adequate antidiabetic effects. However, P. fulgens administered twice the usual dose (900 mg/kg/day) caused significant antidiabetic effects. Compared with metformin and gliclazide, it was found that P. fulgens had similar effects at high doses. Discussion and Conclusion: According to our findings, P. fulgens improves the activity of liver enzymes related to blood glucose and glucose metabolism in diabetic rats and has significant antidiabetic effects.