Correlation of serum fatty acid binding protein-4 and interleukin-6 with airflow limitation and quality of life in stable and acute exacerbation of COPD

Abstract

Background/aim: The serum fatty acid binding protein 4 FABP-4 level increases in chronic inflammatory diseases. The present study aimed to examine serum FABP-4 and interleukin IL -6 levels in patients with stable and acute exacerbation of chronic obstructive pulmonary disease COPD and the correlation of these markers with airflow limitation. Materials and methods: We measured serum FABP-4 and IL-6 levels in 60 COPD patients [30 stable COPD SCOPD , and 30 acute exacerbation of COPD AECOPD ], and 30 healthy subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease GOLD criteria, peripheral O2 saturation SpO2 , and COPD Assessment Test CAT score. We also tested the association between serum FABP-4 levels and some characteristics of study parameters. Results: Both serum FABP-4 and IL-6 levels increased with increasing severity of GOLD grades in SCOPD P