Total oxidant and antioxidant status and paraoxonase 1 levels ofchildren with noncystic fibrosis bronchiectasis

Abstract

Background/aim: To evaluate total oxidant status TOS , total antioxidant capacity TAC , and paraoxonase 1 PON1 levels in children with noncystic fibrosis CF bronchiectasis BE , and to compare these levels with those of healthy controls. The study parameters were also evaluated according to some demographic, anthropometric, and clinical characteristics, as well as lung functions. Materials and methods: Enrolled in the study were 118 children with non-CF BE and 68 healthy controls. Serum TOS, TAC, and PON1 levels were determined. Lung function tests were performed by spirometry. Results: Serum TOS was higher in the patients [median 9.54 IQR 25-75 = 7.05-13.30 µmol H2O2 Eq/L] than in the healthy subjects [6.64 5.45-9.53 µmol H2O2 Eq/L] P