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Dergiler / Journal of Health Sciences and Medicine / 2023 / Cilt: 6 Sayı: 6

The investigation of serum nectin-4 levels in patients with early onset preeclampsia

Züat ACAR
Mehmet OBUT
Zeynep GEDİK ÖZKÖSE
Sadun SUCU
Salim SEZER
Mevlüt BUCAK
İsmail DAĞ
Sezgi Güllü ERCİYESTEPE
İsmail ÖZDEMİR
Sayfa
1193–1199
Yayın Tarihi
2023-10-29
DOI
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Increased nectin-4 levels may contribute to the development of EOPE through possible oxidative, immunological, and inflammatory mechanisms adversely affecting trophoblastic cells.

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Amaç & Hipotez:Aims: We aimed to investigate the level and predictive value of soluble nectin-4 in early onset preeclampsia (EOPE).
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Temel Bulgular & Veri:Methods: Forty-three patients with EOPE and 41 healthy normotensive pregnant women participated in this prospective case-control study.
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Sonuç & Katkı:Increased nectin-4 levels may contribute to the development of EOPE through possible oxidative, immunological, and inflammatory mechanisms adversely affecting trophoblastic cells.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Early preeclampsia · nectin-4 · preeclampsia

Abstract

Aims: We aimed to investigate the level and predictive value of soluble nectin-4 in early onset preeclampsia (EOPE). Methods: Forty-three patients with EOPE and 41 healthy normotensive pregnant women participated in this prospective case-control study. The groups were matched for gestational age and gravidity. Serum nectin-4 levels were compared between groups. The ROC curve was drawn to show the predictive value of nectin-4 for EOPE. Patients were followed up until the end of labor, and perinatal outcomes were recorded. Results: The demographic characteristics of the two groups were similar. Serum nectin-4 level was significantly increased in EOPE cases compared to controls (226.46±119.6 ng/ml vs. 156.54±44.8 ng/ml, p=0.001). The ROC showed that at > 160.938, the sensitivity and specificity were 67.44% and 82.93%, respectively [AUC:0.822, (CI:0.724 - 0.897), and (p< 0.001)]. Significant inverse correlations were found between nectin-4 levels and poor obstetric outcomes. Conclusion: Maternal serum nectin-4 levels were significantly higher in patients with EOPE compared with controls. Increased nectin-4 levels may contribute to the development of EOPE through possible oxidative, immunological, and inflammatory mechanisms adversely affecting trophoblastic cells.

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Bu Makaleye Atıf Yap

ACAR, Z., OBUT, M., ÖZKÖSE, Z. G., SUCU, S., SEZER, S., BUCAK, M., DAĞ, İ., ERCİYESTEPE, S. G., ÖZDEMİR, İ. (2023). The investigation of serum nectin-4 levels in patients with early onset preeclampsia. Journal of Health Sciences and Medicine, Cilt: 6 Sayı: 6, 1193–1199. https://ajindex.com/articles/969239

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Kaynakça (10)

  1. Gestational Hypertension and Preeclampsia: ACOG practice bulletin, number 222. Obstet Gynecol. 2020;135(6):e237. Lisonkova S, Joseph KS. Incidence of preeclampsia: risk factors and outcomes associated with early- versus late-onset disease. Am J Obstet Gynecol. 2013;209(6):544.e1-544.e12. Harmon QE, Huang L, Umbach DM, et al. Risk of fetal death with preeclampsia. Obstet Gynecol. 2015;125(3):628-635.
  2. Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: pathophysiology, challenges, and perspectives. Circ Res. 2019;124(7):1094-1112.
  3. Redman CW, Sargent IL, Staff AC. IFPA Senior Award Lecture: making sense of pre-eclampsia - two placental causes of preeclampsia? Placenta. 2014;35 Suppl:S20-25. Raymond D, Peterson E. A critical review of early-onset and late-onset preeclampsia. Obstet Gynecol Surv. 2011;66(8):497-506.
  4. Obut M, Oğlak SC. Expression of CD44 and IL-10 in normotensive and preeclamptic placental tissue. Ginekol Pol. 2020;91(6):334-341.
  5. Ito M, Nishizawa H, Tsutsumi M, et al. Potential role for nectin-4 in the pathogenesis of pre-eclampsia: a molecular genetic study. BMC Med Genet. 2018;19:166. Wang Y, Walsh SW. TNF alpha concentrations and mRNA expression are increased in preeclamptic placentas. J Reprod Immunol. 1996;32(2):157-169.
  6. Reymond N, Fabre S, Lecocq E, Adelaïde J, Dubreuil P, Lopez M. Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. J Biol Chem. 2001;276(46):43205-43215.
  7. Adu-Gyamfi EA, Czika A, Gorleku PN, et al. The involvement of cell adhesion molecules, tight junctions, and gap junctions in human placentation. Reprod Sci Thousand Oaks Calif. 2021;28(2):305-320.
  8. Fabre-Lafay S, Monville F, Garrido-Urbani S, et al. Nectin-4 is a new histological and serological tumor associated marker for breast cancer. BMC Cancer. 2007;7:73. Karabulut M, Gunaldi M, Alis H, et al. Serum nectin-2 levels are diagnostic and prognostic in patients with colorectal carcinoma. Clin Transl Oncol Off Publ Fed Span Oncol Soc Natl Cancer Inst Mex. 2016;18(2):160-171.
  9. Zhou Y, Damsky CH, Chiu K, Roberts JM, Fisher SJ. Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts. J Clin Invest. 1993;91(3):950-960. Oudejans CBM, van Dijk M, Oosterkamp M, Lachmeijer A, Blankenstein MA. Genetics of preeclampsia: paradigm shifts. Hum Genet. 2007;120(5):607-612.
  10. Esplin MS, Fausett MB, Fraser A, et al. Paternal and maternal components of the pred