Kontrast Madde Nefropatisi: Antioksidan Tedavi Yönetimi

Temel Bulgular & Veri:Çeşitli önleyici tedaviler ve yan etkisi daha az düşük osmolar kontrast maddelere rağmen, klinik pratikte tek önleyici tedavi intravenöz iztonik infüzyonudur.

💡

Sonuç & Katkı:Bu yüzden yeni bir koruyucu tedaviye ihtiyaç vardır.

🔬Tür:Araştırma Makalesi

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Kontrast · kontrast madde nefropatisi · antioksidan tedavi

Özet

Günümüzde görüntüleme ve girişimsel işlemlerin artış göstermesi ile birlikte kontrast madde kullanımı giderek artmıştır. Oksidatif stresin kontrast madde nefropatisi patofizyolojisinde önemli rolü vardır. Çeşitli önleyici tedaviler ve yan etkisi daha az düşük osmolar kontrast maddelere rağmen, klinik pratikte tek önleyici tedavi intravenöz iztonik infüzyonudur. Bu yüzden yeni bir koruyucu tedaviye ihtiyaç vardır.

Abstract

At present, the number of imaging and interventional procedures using contrast agents is gradually increasing. Oxidative stress plays a significant role in its pathophysiology. Despite the use of various prophylactic therapies and low-osmolar contrast agents with lesser adverse effects, intravenous isotonic fluid infusion is the only method that has been proven to be effective in preventing contrast-induced nephropathy in clinic practice. Therefore, a novel kidney-protecting treatment model is required for contrast-induced nephropathy.

Anahtar kelimeler

Kontrast kontrast madde nefropatisi antioksidan tedavi anjiyografi Contrast contrast-induced nephropathy antioxidant treatment angiography

🔖

Bu Makaleye Atıf Yap

BÜYÜKLÜ, M., BAKIRCI, E. M., DEĞİRMENCİ, H., CEYHUN, G., TOPAL, E. (2017). Kontrast Madde Nefropatisi: Antioksidan Tedavi Yönetimi. Koşuyolu Heart Journal, Cilt: 20 - Sayı: 1, 59–62. https://ajindex.com/articles/96735

📄 Tam Metin PDF Okuyucu

Yeni Sekmede Aç ↗

↗Yeni Sekme

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (15)

Asif A, Epstein M. Prevention of radiocontrast-induced nephropathy. Am J Kidney Dis 2004;44:12-24
Wong PC, Li Z, Guo J, Zhang A. Pathophysiology of contrast-induced nephropathy. Int J Cardiol 2012;158:186-92
Persson PB. Contrast-induced nephropathy. Eur Radiol Suppl 2005;4:65-9
Ozkan G, Ulusoy S, Orem A, Ersoz S, Alkanat M, Yucesan FB, et al. Protective effect of the grape seed proanthocyanidin extract in a rat model of contrast-induced nephropathy. Kidney Blood Press Res 2012;35:445-53
Tepel M, van der Giet M, Schwarzfeld C, Laufer U, Liermann D, Zidek W. Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine. N Engl J Med 2000;343:180-4
Gonzales DA, Norsworthy KJ, Kern SJ, Banks S, Sieving PC, Star RA, et al. A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. BMC Med 2007;5:32
Spargias K, Alexopoulos E, Kyrzopoulos S, Iokovis P, Greenwood DC, Manginas A, et al. Ascorbic acid prevents contrast-mediated nephropathy in patients with renal dysfunction undergoing coronary angiography or intervention. Circulation 2004;110:2837-42
Boscheri A, Weinbrenner C, Botzek B, Reynen K, Kuhlisch E, Strasser RH. Failure of ascorbic acid to prevent contrast-media induced nephropathy in patients with renal dysfunction. Clin Nephrol 2007;68:279-86
Jo SH, Koo BK, Park JS, Kang HJ, Kim YJ, Kim HL, et al. N-acetylcysteine versus ascorbic acid for preventing contrast-induced nephropathy in patients with renal insufficiency undergoing coronary angiography NASPI study-a prospective randomized controlled trial. Am Heart J 2009;157:576-83
Zhou L, Chen H. Prevention of contrast-induced nephropathy with ascorbic acid. Intern Med 2012;51:531-5
Golbidi S, Badran M, Laher I. Diabetes and alpha lipoic Acid. Front Pharmacol 2011;2:69
Jo SH, Kim SA, Kim HS, Han SJ, Park WJ, Choi YJ. Alpha-lipoic acid for the prevention of contrast-induced nephropathy in patients undergoing coronary angiography: the ALIVE study - a prospective randomized trial. Cardiology 2013;126:159-66
Cicek M, Yıldırır A, Okyay K, Yazici AC, Aydinalp A, Kanyilmaz S, et al. Use of alpha-lipoic acid in prevention of contrast-induced nephropathy in diabetic patients. Ren Fail 2013;35:748-53
Kongkham S, Sriwong S, Tasanarong A. Protective effect of alpha tocopherol on contrast-induced nephropathy in rats. Nefrologia 2013;33:116-23
Tasanarong A, Vohaki