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Dergiler / Hacettepe Journal of Biology and Chemistry / 2023 / Cilt: 51 Sayı: 3

Antidiabetic and antioxidant effect of Origanum minutiflorum O. Schwarz & P. H. Davis in streptozotocin-induced diabetic rats

İsmail Bayram GÜLLÜ
Sevil ALBAYRAK
Emin KAYMAK
Arzu YAY
Sayfa
259–270
Yayın Tarihi
2023-07-16
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

These scientific results confirm the use of O. minutiflorum as adjuvant antidiabetic therapy.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In this study, the antidiabetic potential of aqueous extract of Origanum minutiflorum was tested using streptozotocin induced diabetic rats.
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Temel Bulgular & Veri:The administration of aqueous extract and carvacrol to diabetic group rats caused significant decrease in blood glucose, biochemical parameters of serum and significantly increased the concentration of high density lipoprotein cholesterol.
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Sonuç & Katkı:These scientific results confirm the use of O. minutiflorum as adjuvant antidiabetic therapy.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Antidiabetic activity · Antioxidant activity · Carvacrol

Abstract

In this study, the antidiabetic potential of aqueous extract of Origanum minutiflorum was tested using streptozotocin induced diabetic rats. Changes in body weight, blood glucose level, biochemical parameters, antioxidant enzyme activities and histopathological examination of kidney were evaluated. The administration of aqueous extract and carvacrol to diabetic group rats caused significant decrease in blood glucose, biochemical parameters of serum and significantly increased the concentration of high density lipoprotein cholesterol. The administration of aqueous extract and carvacrol significantly increased the antioxidant enzyme activity and reduced the MDA level. The histopathological analysis of kidney showed that aqueous extract and carvacrol had possible ameliorative effect against kidney damage. Aqueous extract is also showed α-amylase and α-glucosidase inhibitor activity with high antioxidant activity. These scientific results confirm the use of O. minutiflorum as adjuvant antidiabetic therapy.

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Bu Makaleye Atıf Yap

GÜLLÜ, İ. B., ALBAYRAK, S., KAYMAK, E., YAY, A. (2023). Antidiabetic and antioxidant effect of Origanum minutiflorum O. Schwarz & P. H. Davis in streptozotocin-induced diabetic rats. Hacettepe Journal of Biology and Chemistry, Cilt: 51 Sayı: 3, 259–270. https://ajindex.com/articles/955411

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Kaynakça (14)

  1. A.M. Vincent, J.W. Russell, P. Low, E.L. Feldman, Oxidative stress in the pathogenesis of diabetic neuropathy, Endocr. Rev., 25 (2004) 612-628.
  2. Z.G. Li, W. Zhang, G. Grunberger, A.A.F. Sima, Hipocampal Neuronal Apoptosis in Type1 Diabetes, Brain Res., 946 (2002) 221–231.
  3. Z. Çambay, Investigation of the effects of Pomegranate (Punica granatum) flower on aspartate aminotransferase and alanine aminotransferase levels in diabetic rats serum, Ecol. Life Sci., 6 (2011) 124–133.
  4. A. Yönem, M. Özata, Diabetes Mellitus: Diagnosis, Classification, Clinical Features, Istanbul Medical Publishing, 2006.
  5. I. Satman, T. Yilmaz, A. Sengul, S. Salman, F. Salman, S. Uygur, I. Bastar, Y. Tutuncu, M. Sargin, N. Dinccag, K. Karsidag, S. Kalaca, C. Ozcan, H. King, Population-based study of diabetes and risk characteristics in Turkey: results of the Turkish Diabetes Epidemiology Study (TURDEP), Diabetes Care, 25 (2002) 1551–1556.
  6. M.P. Kahkonen, A.I. Hopia, H.J. Vuorela, J.P. Rauha, K. Pihlaja, T.S. Kujala, M. Heinonen, Antioxidant activity of plant extracts containing phenolic compounds, J. Agric. Food Chem., 47 (1999) 3954–3962.
  7. S. Oksana, B. Marian, R. Mahendra, S.H. Bo, Plant phenolic compounds for food, pharmaceutical and cosmetiсs production, J. Med. Plants Res., 6 (2012) 2526–2539.
  8. D.M. Pereira, P. Valentão, J.A. Pereira, P.B. Andrade, Phenolics: From Chemistry to Biology, Molecules, 14 (2009) 2202–2211.
  9. M.J. Balunas, A.D. Kinghorn, Drug discovery from medicinal plants, Life Sci., 78 (2005) 431–441.
  10. J. Anita, S.S. Katewa, P.K. Galav, N. Ambika, Unrecorded Ethnomedicinal Uses of Biodiversity from Tadgarh-Raoli Wildlife Sanctuary, Rajasthan, India, Acta Bot. Yunnanica, 29 (2007) 337–344.
  11. S. Albayrak, A. Aksoy, Phenolic contents and biological activity of endemic Origanum minutiflorum grown in Turkey, Indian J. Pharm. Educ. Res., 53 (2019) 160–169.
  12. A. Lemhadri, N.A. Zeggwagh, M. Maghrani, H. Jouad, M. Eddouks, Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region, J. Ethnopharmacol., 92 (2004) 251–256.
  13. S. Albayrak, A. Aksoy, O. Sagdic, E. Hamzaoglu, Compositions, antioxidant and antimicrobial activities of Helichrysum (Asteraceae) species collected from Turkey, Food Chem., 119 (2010) 114–122.
  14. G. Zengin, C. Sarikurkcu, A. Aktumsek, R. Ceylan, O. Ceylan, A comprehensive study on phytochemical characterization of Haplophyllum myrtifolium Boiss endemic to Turkey and its inhibitory potential against key enzymes involved in Alzheimer