Furthermore, in vitro experiments did conducted on the AGS (gastric cancer cell) line and the HaCaT (keratinocyte normal cell) line to elucidate the effects of caffeic acid in these cellular systems.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Caffeic acid, a prominent antioxidant compound, has garnered significant attention in research due to its multifaceted properties, which include anti-inflammatory, antiobesogenic, antithrombotic, vasodilating, and antitumor activities.
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Temel Bulgular & Veri:This study aims to comprehensively investigate the impact of caffeic acid on various metabolic enzymes (carbonic anhydrase I, II, IX, and glutathione reductase) through both in silico and in vitro approaches.
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Sonuç & Katkı:Furthermore, in vitro experiments did conducted on the AGS (gastric cancer cell) line and the HaCaT (keratinocyte normal cell) line to elucidate the effects of caffeic acid in these cellular systems.
Caffeic acid, a prominent antioxidant compound, has garnered significant attention in research due to its multifaceted properties, which include anti-inflammatory, antiobesogenic, antithrombotic, vasodilating, and antitumor activities. This study aims to comprehensively investigate the impact of caffeic acid on various metabolic enzymes (carbonic anhydrase I, II, IX, and glutathione reductase) through both in silico and in vitro approaches. Furthermore, in vitro experiments did conducted on the AGS (gastric cancer cell) line and the HaCaT (keratinocyte normal cell) line to elucidate the effects of caffeic acid in these cellular systems.
KARAGÖZ, L., ŞENTÜRK, M., SAĞIR, T., KARAGÖZ, Y., BATMAZ, O. S., KURBAN, M. G. (2023). Investigation of Caffeic Acid Effect on Human Cancer Cell Line and Some Enzymes. Eastern Anatolian Journal of Science, Cilt: 9 Sayı: 1, 33–42. https://ajindex.com/articles/952037
ABDEL-AZIZ AA-M, EL-AZAB AS, EKINCI D, SENTURK M, SUPURAN CT. 2015. Investigation of arenesulfonyl-2-imidazolidinones as potent carbonic anhydrase inhibitors. J Enzym Inhib Med Chem. 30(1):81-84.
AGUNLOYE OM, OBOH G, ADEMILUYI AO, ADEMOSUN AO, AKINDAHUNSI AA, OYAGBEMI AA, et al. 2019. Cardio-protective and antioxidant properties of caffeic acid and chlorogenic acid: mechanistic role of angiotensin converting enzyme, cholinesterase and arginase activities in cyclosporine induced hypertensive rats. Biomed Pharmacother. 109:450-458.
ARSLAN T, CELIK G, CELIK H, SENTURK M, YAYLI N, EKINCI D. 2016. Synthesis and Biological Evalution of Novel Bischalcone Derivatives as Carbonic Anhydrase Inhibitors. Archive der Pharmazie. 349(9):741-748.
ARSLAN T, TURKOGLU EA, SENTURK M, SUPURAN CT. 2016. Novel chalcone substituted benzenesulfonamides as inhibitors for human carbonic anhydrases. Bioorg Med Chem Lett. 26(24):5867-5870.
ARSLAN T, CEYLAN MB, BAS H, BIYIKLIOGLU Z, SENTURK M. 2020.
Design, Synthesis, Characterization of Novel Peripherally Tetra 1,2,3-Triazole Substituted Phthalocyanines and Inhibitor Effect on Cholinesterases (AChE/BChE) and Carbonic Anhydrases (hCA I, II and IX). Dalton Trans. 49:203-209.
AYGUN B, SENTURK M, CINAN E, SIMSEK O, SAYYED MI, KARABULUT A. 2022. Determination of Biological Radioprotective Characteristics of some natural organic compounds for Radiation Shielding Applications. Radiochimica Acta. https://doi.org/10.1515/ract-2022-0028.
BALENDIRAN GK, DABUR R, FRASER D. 2004. The role of glutathione in cancer. Cell Biochem Funct 22:343-352. BEUTLER E. 1984. Red cell metabolism. A manual of biochemical methods. Grune and Stratton Inc, Orlando. ISBN: 0808916726 9780808916727. BOEHME CC, ARSCOTT LD, BECKERK, SCHIRMER RH, WILLIAMS CH. 2000. Kinetic characterization of glutathione reductase from the malarial parasite Plasmodium falciparum Comparison with the human enzyme. J Biol Chem. 275:37317-37323.
CAKMAK R, DURDAGI S, EKINCI D, SENTURK M, TOPAL G. 2011. Design, synthesis and biological evaluation of novel nitroaromatic compounds as potent glutathione reductase inhibitors. Bioorg Med Chem Lett. 21;5398-5402.
CHEN JH, HO CT. 1997. Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds. J Agric Food Chem. 45:2374-2378.
COBAN TA, SENTURK M, CIFTCI M, KUFREVIOGLU OI. 2007. Effects of some metal ions on human erythrocyte glutathione reductase: an in vitro study. Protein Peptide Lett. 14(10)1027-1030.