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Dergiler / Middle Black Sea Journal of Health Science / 2023 / Cilt: 9 Sayı: 2

Effectıveness of Curcumın on Tracheal Anastomosıs Created in the Rat Model

Muhammed Gazi YILDIZ
Emine KILINÇ
Nida YALÇIN
Dogan ÇAKAN
İsrafil ORHAN
İrfan KARA
Atila YOLDAŞ
Adem DOĞANER
Sayfa
363–375
Yayın Tarihi
2023-05-31
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

We found the positive effect of Curcumin in the prevention of stenosis following tracheal injury.

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Amaç & Hipotez:Objective: We aimed to investigate the effect of curcumin on tracheal wound healing in the anastomosis model following tracheal incision in rats.
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Temel Bulgular & Veri:A horizontal incision was made between the 2nd-3th rings of the rat trachea and damage was created in the inner tracheal mucosa.
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Sonuç & Katkı:We found the positive effect of Curcumin in the prevention of stenosis following tracheal injury.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Rat · Trachea · Stenosis

Abstract

Objective: We aimed to investigate the effect of curcumin on tracheal wound healing in the anastomosis model following tracheal incision in rats. Methods: Twenty-one healthy male Wistar Albino rats were included in the study. A horizontal incision was made between the 2nd-3th rings of the rat trachea and damage was created in the inner tracheal mucosa. Tracheal incision area was sutured and anastomosis was performed. Rats were divided into three groups. Ringer was given to the first group, corticosteroids to the 2nd group, and curcumin to the 3rd group for 28 days. The rats were sacrificed on the 28th day and the tracheal anastomosis line samples were sent for histological examination. Wound healing parameters, tracheal lumen width, wall thickness, and stenosis index were evaluated. Results: Statistically significant difference was detected in tracheal lumen width and wall thickness in the curcumin group (p<0.05). Statistically significant differences were observed in the curcumin group in parameters of inflammation, collagen production and fibrosis. (p<0.05). Conclusion: It is important to prevent the formation of tracheal stenosis, which is difficult to treat in clinical practice. Desired results cannot be achieved in the side-effect profile of some medical drugs used in this regard. We found the positive effect of Curcumin in the prevention of stenosis following tracheal injury.

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Bu Makaleye Atıf Yap

YILDIZ, M. G., KILINÇ, E., YALÇIN, N., ÇAKAN, D., ORHAN, İ., KARA, İ., YOLDAŞ, A., DOĞANER, A. (2023). Effectıveness of Curcumın on Tracheal Anastomosıs Created in the Rat Model. Middle Black Sea Journal of Health Science, Cilt: 9 Sayı: 2, 363–375. https://ajindex.com/articles/937971

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Kaynakça (15)

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