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Dergiler / Cerrahi Sanatlar Dergisi / 2023 / Cilt: 16 - Sayı: 1

Potential independent risk factors associated with vitamin D deficiency in the post liver transplant patients

Arif ATAY
Deniz YAVUZ BAŞKIRAN
Adil BASKİRAN
Sezai YILMAZ
Sayfa
1–5
Yayın Tarihi
2023-01-31
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Therefore, serum 25(OH)D3 levels of the patients after liver transplantation should be monitored regularly.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background: Deficiency of native vitamin D [cholecalciferol, 25(OH)D3] is a common in patients with end stage liver failure.
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Temel Bulgular & Veri:Aim: Our study aimed to determine the risk factors and their frequency associated with 25(OH)D3 deficiency after liver transplantation.
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Sonuç & Katkı:Therefore, serum 25(OH)D3 levels of the patients after liver transplantation should be monitored regularly.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:25(OH)D3 · liver transplantation · deficiency

Abstract

Background: Deficiency of native vitamin D [cholecalciferol, 25(OH)D3] is a common in patients with end stage liver failure. Aim: Our study aimed to determine the risk factors and their frequency associated with 25(OH)D3 deficiency after liver transplantation. Method: This study includes the patients with liver transplantation and carried out at the tertiary care center. Serum 25(OH)D3 levels were measured in those patients. Results: A total of 148 patients were entered the study. Chronic viral hepatitis was the most common reason for transplantation (66.2%). Postoperative follow-up period was shorter than 1 year in eightytwo patients (55.4 %). Post-transplant 25(OH)D3 levels were below 20 ng/mL in 93 (62.8 %) patients Post-transplant 25(OH)D3 deficiency was greater in patients with follow-up periods shorter than 1 year (p = <0.001), in those receiving immunosupression with mycophenolate mofetil, tacrolimus, steroids and in those with low hematocrit rate and, albumin levels. On multivariate analysis, post-transplant follow-up period shorter than 1 year (OR: 6.18, 95% CI: 2.681-14.255, p<0.001) and steroid use in chronic immunosuppression (OR: 9.47, 95% CI: 1.165-77.009, p=0.035) were detected asindependent accompanying factors with 25(OH)D3 deficiency. Conclusions: The The risk of 25(OH)D3 deficiency in p atients receiving immunosuppressive treatment with steroids to prevent rejection or those in the first post-transplant year was high. Therefore, serum 25(OH)D3 levels of the patients after liver transplantation should be monitored regularly.

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Bu Makaleye Atıf Yap

ATAY, A., BAŞKIRAN, D. Y., BASKİRAN, A., YILMAZ, S. (2023). Potential independent risk factors associated with vitamin D deficiency in the post liver transplant patients. Cerrahi Sanatlar Dergisi, Cilt: 16 - Sayı: 1, 1–5. https://ajindex.com/articles/877964

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Kaynakça (10)

  1. Sylvester FA. Bone abnormalities in gastrointes-tinal and hepatic disease. Curr Opin Pediatr 1999;11: 402-407.
  2. Southerland JC, Valentine JF. Osteopenia and osteoporosis in gastrointestinal diseases: Diag-nosis and treatment. Curr Gastroenterol Rep 2001;3:399-407.
  3. Ginde AA, Liu MC, Camargo CA Jr. Demog-raphic differences and trends of vitamin D in-sufficiency in the US population, 1988–2004. Arch Intern Med 2009;23:626-632.
  4. Maalouf NM, Shane E. Osteoporosis after solid organ transplantation. J Clin Endocrinol Metab 2005;90:2456-2465. D’antiga L, Moniz C, Buxton-Thomas M, Che-eseman P, Gray B, Abraha H, et al. Bone mine-ral density and height gain in children with chronic cholestatic liver disease undergoing transplantation. Transplantation 2002;73:1788-1793.
  5. Eyal O, Aharon M, Safadi R, Elhalel MD. Se-rum vitamin D levels in kidney transplant reci-pients: the importance of an immunosuppres-sion regimen and sun exposure. Isr Med Assoc J 2013;15:628-633.
  6. Pascussi JM, Robert A, Nguyen M, Walrant-Debray O, Garabedian M, Martin P, et al. Pos-sible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. J Clin Invest 2005;115:177-186.Morris HA. Vitamin D: A hormone for all sea-sons–how much is enough? Clin Biochem Rev 2005;26:21-32.
  7. Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML. Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001–2004. Pediatrics 2009;124:371-379. Reis JP, von Mühlen D, Miller ER 3rd, Michos ED, Appel LJ. Vitamin D status and cardiome-tabolic risk factors in the United States adoles-cent population. Pediatrics 2009;124:371-379.
  8. Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovascular disease and vitamin D insuffici-ency into perspective. Br J Nutr 2005;94:483-492.
  9. Branch AD, Barin B, Rahman A, Stock P, Schiano TD. Vitamin D status of human immu-nodeficiency virus-positive patients with ad-vanced liver disease enrolled in the solid organ transplantation in HIV: Multi-site study. Liver Transpl 2014;20:156-164.
  10. Valta H, Jalanko H, Holmberg C, Helenius I, Mäkitie O. Impaired bone health in adolescents after liver transplantation. Am J Transplant 2008;8:150-157. D’antıga L, Ballan D, Luisetto G, Cillo U, Guari-so G, Zancan L. Long-term outcome of bone mineral density in children who underwent a successful liver transplantation. Transplantation 2004;78:899-903. American Diabetes Association. Standards of Medical Care in Diabetes-2011. Diabetes Care 2011;34:11-61. Zh