Yapay Zeka Hızlı Bakış & Çıkarımlar
AI InsightIt is claimed that new voltammetric methods can be used routinely MX analysis in PFs.
📌 3 Maddede Bu Makale
Abstract
Two new voltammetric methods (square wave (SWV) and differential pulse (DPV)) were developed and validated for the direct determination of meloxicam (MX) in pharmaceutical formulations (PFs) without any pre-processes steps. The anodic peaks were obtained in buffer (pH 4.85) on glassy carbon electrode (GCE). The both voltammetric methods were linear at concentration range of 10-90 µg/mL in PF. The validation of methods for MX in PF were determined by establishing specificity, linearity, sensitivity, precision, accuracy, recovery and ruggedness. The recovery results of MX in PFs were found as % 98.5 for SWV and % 98.7 for DPV, respectively. The both developed voltammetric methods were successfully applied for the determination of MX in PFs named Melox, Melcam and Zeloxim. The endogenous substances found in PF were not create electroactive interferences for determine MX. The obtained analysis results of the PFs containing MX by voltammetric methods were compared by using the student t-test with the claimed values and no found statistically differences. It is claimed that new voltammetric methods can be used routinely MX analysis in PFs.