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Dergiler / Journal of Physical Chemistry and Functional Materials / 2022 / Cilt: 5 - Sayı: 2

Investigation of K-Serotonin Structure Using Nuclear Magnetic Resonance by Quantum Chemical Methods

Mücahit YILMAZ
Hanifi KEBİROGLU
Sayfa
49–55
Yayın Tarihi
2022-12-12
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

By calculating the values for 5-HT and K-5-HT, the effects of potassium on 5-HT binding were compared.

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Amaç & Hipotez:In this study, the K-Serotonin structure formed by adding potassium to Serotonin (5-HT) was investigated by quantum chemical methods. 5-hydroxytryptamine is a neurotransmitter that affects mood, making people feel happy and energetic. 5-HT and 5-HT-potassium were optimized with some base sets to find the optimal band gap using the density function theory (DFT) and Hartree-Fock (HF) method.
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Temel Bulgular & Veri:The most suitable DFT/LanL2DZ was selected for the structure with and without additives.
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Sonuç & Katkı:By calculating the values for 5-HT and K-5-HT, the effects of potassium on 5-HT binding were compared.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Serotonin (5-HT) · K-Serotonin (K-5-HT) · DFT

Abstract

In this study, the K-Serotonin structure formed by adding potassium to Serotonin (5-HT) was investigated by quantum chemical methods. 5-hydroxytryptamine is a neurotransmitter that affects mood, making people feel happy and energetic. 5-HT and 5-HT-potassium were optimized with some base sets to find the optimal band gap using the density function theory (DFT) and Hartree-Fock (HF) method. The most suitable DFT/LanL2DZ was selected for the structure with and without additives. By calculating the values for 5-HT and K-5-HT, the effects of potassium on 5-HT binding were compared.

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Bu Makaleye Atıf Yap

YILMAZ, M., KEBİROGLU, H. (2022). Investigation of K-Serotonin Structure Using Nuclear Magnetic Resonance by Quantum Chemical Methods. Journal of Physical Chemistry and Functional Materials, Cilt: 5 - Sayı: 2, 49–55. https://ajindex.com/articles/869354

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  1. Referans1 B. L. Jacobs and E. C. Azmitia, (1992). Structure and function of the brain 5-HT system, Physiological Reviews 1992 72:1, 165-229. Referans2 Mark Tricklebank (Editor), Eileen Daly (Editor), (2019). The 5-HT System: History, Neuropharmacology, and Pathology 1st Edition, Academic Press. Referans3 Whitaker-Azmitia, P., (1999). The Discovery of 5-HT and its Role in Neuroscience. Neuropsychopharmacol 21 (Suppl 1), 2–8, https://doi.org/10.1016/S0893-133X(99)00031-7 Referans4 Bowker RM, Westlund KN, Coulter JD. Origins of serotonergic projections to the spinal cord in rat: an immunocyto-chemical-retrograde transport study. Brain Res. 1981;226(1-2):187-99. oi: 0006-8993(81)91092-1 Referans5 Perrier J. F. (2016). Modulation of motoneuron activity by serotonin. Danish medical journal, 63(2), B5204. Referans6 Torres, S., Nowson, C., & Worsley, A. (2008). Dietary electrolytes are related to mood. British Journal of Nutrition, 100(5), 1038-1045. doi:10.1017/S0007114508959201 Referans7 Lack, B. Daya, S. and Nyokong, T. (2001), Interaction of 5-HT and melatonin with sodium, potassium, calcium, lithium and aluminium. Journal of Pineal Research, 31: 102-108. https://doi.org/10.1034/j.1600-079x.2001.310202.x Referans8 Torres, S., Nowson, C., & Worsley, A. (2008). Dietary electrolytes are related to mood. British Journal of Nutrition, 100(5), 1038-1045. doi:10.1017/S0007114508959201 Referans9 Dluhy, R. G., Axelrod, L., Underwood, R. H., & Williams, G. H. (1972). Studies of the control of plasma aldosterone concentration in normal man. II. Effect of dietary potassium and acute potassium infusion. The Journal of clinical investigation, 51(8), 1950–1957. https://doi.org/10.1172/JCI107001 Referans10 Dennington R.D., Keith T.A., Millam J.M., GaussView 6.0. 16, Semichem. Inc., Shawnee Mission KS, 2016. Referans11 Frisch M.J., Trucks G.W., Schlegel H.B., Scuseria G.E., Robb M.A., Cheeseman J.R., Nakatsuji H., Gaussian09 Revision D. 01, Gaussian Inc.,Wallingford CT, 2009. http://www.gaussian.com. Referans12 Becke A. D., Perspective: Fifty years of density-functional theory in chemical physics, The Journal of Chemical Physics, 140(18) (2014) 18A301. Referans13 Lee C., Yang W., Parr R. G., Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density, Physical Review B., 37(2) (1988) 785. Referans14 Zhao Y., Truhlar D. G., The M06 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interac