Dergiler / The Ulutas Medical Journal / 2019 / Cilt: 5 - Sayı: 1

The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis

Sayfa
60–64
Yayın Tarihi
2019-01-01
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In group I and group II, recovery time was significantly different p

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Introduction: Herpes simplex virus is a common keratitis agent.
📊
Temel Bulgular & Veri:There are two different types of virus, type 1 and 2.
💡
Sonuç & Katkı:In group I and group II, recovery time was significantly different p
🔬Tür:Araştırma Makalesi
📍Kapsam:2017 Verileri
⚙️Değişkenler:Herpetic epithelial keratitis · ganciclovir · oxytetracycline HCl

Abstract

Introduction: Herpes simplex virus is a common keratitis agent. There are two different types of virus, type 1 and 2. Type 1 shows three main clinical pictures in cornea: epithelial herpetic keratitis, stromal keratitis, disciform keratitis. The aim of this study is to reduce the duration of herpetic keratitis treatment and eliminate the risk of complications. Material and Methods: Between January 2017 and January 2018, 29 patients with herpetic keratitis were included in the study. In the first group, the herpetic membrane was removed by a single shot on the herpetic lesion with the yag laser. Then, topically oxytetracycline hydrochloride+polymyxin B sulfate was applied. The second group was treated with topical antiviral therapy Ganciclovir . After treatment, daily follow-up of patients, vision, tonus, fundus diameters and recovery times were noted and the data were compared statistically. Results: In group I and group II, the age of the patients did not differ significantly p> 0.05 . In group I and group II, the gender distribution of the patients did not differ significantly p>0.05 . In Group I and Group II, the degree of vision did not differ significantly p>0.05 . In group I and group II, the examination findings were not significant p>0.05 . In group I and group II, recovery time was significantly different p

🔖

Bu Makaleye Atıf Yap

GUVENMEZ, O., KAYİKLİK, A. (2019). The Effectiveness of Ganciclovir Comparing with Combination Therapy of Oxytetracycline HCI and Polymyxin B Sulfate in Herpetic Epithelial Keratitis. The Ulutas Medical Journal, Cilt: 5 - Sayı: 1, 60–64. https://ajindex.com/articles/844438

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (1)

  1. Darougar S, Wishart MS, Viswalingam ND. Epidemiological and clinical features of primary herpes simplex virus ocular infection. Br J Ophthalmol. 1985;69(1):2–6 2. Liesegang TJ, Melton LJ, Daly PJ, Ilstrup DM. Epidemiology of ocular herpes simplex: incidence in Rochester, Minn, 1950 through 1982. Arch Ophthalmol. 1989;107(8):1155–1159 3. Tang Q, Chen W, Hendricks RL. Proinflammatory functions of IL-2 in herpes simplex virus corneal infection. J Immunol. 1997;158(3):1275–1283 4. Tsatsos M, MacGregor C, Athanasiadis I, Moschos MM, Hossain P, Anderson D. Herpes simplex virus keratitis: an update of the pathogenesis and current treatment with oral and top- ical antiviral agents. Clin Exp Ophthalmol. 2016;44(9):824–837 5. White ML, Chodosh J. Herpes simplex virus keratitis; A Treatment Guideline. 2014. Massachusetts Eye and Ear Infirmary Department of Ophthalmology, Harvard Medical School. Reviewed and endorsed by the Ocular Microbiology and Immunology Group 6. Farooq AV, Shukla D. Herpes simplex epithelial and stromal keratitis: an epidemiologic update. Surv Ophthalmol. 2012;57(5):448–62 7. Miserocchi E, Modorati G, Galli L, Rama P. Efficacy of valacyclovir vs. acyclovir for the prevention of recurrent herpes simplex virus eye disease: A pilot study. Am J Ophthalmol. 2007;144(4):547–51 8. Chong DY, Johnson MW, Huynh TH, Hall EF, Comer GM, Fish DN. Vitreous penetration of orally administered famciclovir. Am J Ophthalmol. 2009;148(1):38–42 9. Roozbahani M, Hammersmith KM. Management of herpes simplex virus epithelial keratitis. Curr Opin Ophthalmol. 2018; 29(4): 360-364 10. Komoto S, Higaki S, Fukuda M, et al. Effects of antiviral medications on herpetic epithelial keratitis in mice. Jpn J Ophthalmol 2015; 59:194-200 11. Sozen E, Avunduk AM, Akyol N. Comparison of efficacy of oral valacyclovir and topical acyclovir in the treatment of herpes simplex keratitis: a randomized clinical trial. Chemo therapy 2006; 52:29-31 12. Loutsch JM, Sainz B Jr, Marquart ME, et al. Effect of famciclovir on herpes simplex virus type 1 corneal disease and establishment of latency in rabbits. Antimicrob Agents Chemother 2001; 45:2044-2053