KaydedilenlerDerginizi ekleyin

Dergiler / Türk Fen ve Sağlık Dergisi / 2021 / Cilt: 2 - Sayı: 3

Antiviral Effects of Some Flavonoids on SARS-CoV-2

Aynur MÜDÜROĞLU KIRMIZIBEKMEZ
Cihan Mehmet ALTINTAŞ
Ali ARSLAN
Ihsan KARA
Sayfa
24–34
Yayın Tarihi
2021-09-30
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Studies investigating the antiviral activity of flavonoids on SARS-CoV-2 should be directed to those other than oleuropein, hesperidin, EGCG, and Myricetin.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Covid-19 disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a global epidemic that affects millions of lives.
📊
Temel Bulgular & Veri:In silico studies have suggested that different flavonoids play an antiviral role against SARS-CoV-2.
💡
Sonuç & Katkı:Studies investigating the antiviral activity of flavonoids on SARS-CoV-2 should be directed to those other than oleuropein, hesperidin, EGCG, and Myricetin.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Covid-19 · EGCG · Hesperidin

Abstract

Covid-19 disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a global epidemic that affects millions of lives. To date, there is no definitive cure for the disease and global vaccination efforts with newly produced vaccines will take years to complete. In silico studies have suggested that different flavonoids play an antiviral role against SARS-CoV-2. In this study, based on in silico findings, we examined the in vitro effects of four promising flavonoids, Hesperidin, Oleuropein, Epigallocatechin gallate (EGCG), and Myricetin. First, we extracted these flavonoids from natural plant sources and purified by using liquid chromatography (LC). Next, we analysed the cell toxicity and antiviral activity of these four flavonoids at different concentrations against SARS-CoV-2. Our results using the SARS-CoV-2 infected Vero E6 cell model were found to contradict previous in silico findings, and these flavonoids were found to have no antiviral effects in vitro. Studies investigating the antiviral activity of flavonoids on SARS-CoV-2 should be directed to those other than oleuropein, hesperidin, EGCG, and Myricetin.

🔖

Bu Makaleye Atıf Yap

KIRMIZIBEKMEZ, A. M., ALTINTAŞ, C. M., ARSLAN, A., KARA, I. (2021). Antiviral Effects of Some Flavonoids on SARS-CoV-2. Türk Fen ve Sağlık Dergisi, Cilt: 2 - Sayı: 3, 24–34. https://ajindex.com/articles/811489

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (8)

  1. Adem, S., Eyupoglu, V., Sarfraz, I. et al. (2020). Identification of Potent COVID-19 Main Protease (Mpro) Inhibitors from Natural Polyphenols: An in silico Strategy Unveils a Hope against CORONA. Preprints. doi:10.20944/preprints202003.0333.v1 Aouidi, F., Dupuy, N., Artaud, J. et al. (2012). Rapid quantitative determination of oleuropein in olive leaves (Olea europaea) using mid-infrared spectroscopy combined with chemometric analyses. Industrial Crops and Products, 37, 292-297. https://doi.org/10.1016/j.indcrop.2011.12.024
  2. Bastolla, U. (2021). Mathematical model of SARS-Cov-2 propagation versus ACE2 fits COVID-19 lethality across age and sex and predicts that of SARS. Frontiers in Molecular Biosciences, 8, 706122. https://doi.org/10.3389/fmolb.2021.706122
  3. Boonpawa, R., Spenkelink, A., Punt, A. et al. (2017). Physiologically based kinetic modeling of hesperidin metabolism and its use to predict in vivo effective doses in humans. Molecular Nutrition Food Research, 61(8), 1600894. https://doi.org/10.1002/mnfr.201600894
  4. Carneiro, B. M., Batista, M. N., Braga, A. C. S. et al. (2016). The green tea molecule EGCG inhibits Zika virus entry. Virology, 496, 215-218. https://doi.org/10.1016/j.virol.2016.06.012
  5. Chacko, S. M., Thambi, P.T., Kuttan, R. et al. (2010). Beneficial effects of green tea: a literature review. Chinese Medicine, 5, 13. https://doi.org/10.1186/1749-8546-5-13
  6. Chen, Y. W., Yiu, C-P. B., Wong, K-Y. (2020). Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates. F1000Research, 9, 129. https://doi.org/10.12688/f1000research.22457.2
  7. Ciesek, S., Hahn von T., Colpitts, C. et al. (2011). The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry. Hepatology, 54(6), 1947-55. https://doi.org/10.1002/hep.24610 Cifá, D., Skrt, M., Pittia, P. et al. (2018). Enhanced yield of oleuropein from olive leaves using ultrasound-assisted extraction. Food Science & Nutrition, 6, 1128-37. https://doi.org/10.1002/fsn3.654
  8. Clercq, E. De. (2000). Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection. Medicinal Research Reviews, 20, 323-349. https://doi.org/10.1002/1098-1128(200009)20:5 3.0.CO;2-A Conti, C., Genovese, D., Santoro, R. et al. (1990). Activities and mechanisms of action of halogen-substituted flavanoids against poliovirus type 2 infection in vitro. Antimicrobial Agents and Che