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Dergiler / Turkish Journal of Veterinary Research / 2021 / Cilt: 5 - Sayı: 2

Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE)

Sevim ÇİFTÇİ YEGİN
Yeter DEĞER
Semiha DEDE
Fatmagül YUR
Sayfa
67–71
Yayın Tarihi
2021-11-15
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: As a result, it was determined that aminoglycosin administered increased serum ACE activity and it was concluded that it may be useful to investigate the possibilities to evaluate it as a risk factor and indicator in the development of hypertension

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: The research attention to nephrotoxicity from antibiotics (as aminoglycosides), non-steroidal anti-inflammatory drugs, and antifungals, angiotensin-converting enzyme (ACE) inhibitors.
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Temel Bulgular & Veri:Material-Method: In this study, two different groups formed, the control group (10 rats/Wistar-albino female) and the experimental group (30 rats/Wistar-albino female) administered aminoglycosine (Amikacin).
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Sonuç & Katkı:Conclusion: As a result, it was determined that aminoglycosin administered increased serum ACE activity and it was concluded that it may be useful to investigate the possibilities to evaluate it as a risk factor and indicator in the development of hypertension
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Aminoglycosides · Angiotensin-Converting Enzyme · Antibiotics

Abstract

Objective: The research attention to nephrotoxicity from antibiotics (as aminoglycosides), non-steroidal anti-inflammatory drugs, and antifungals, angiotensin-converting enzyme (ACE) inhibitors. Several drugs have resulted in produce an adverse effect on kidneys. Angiotensin-converting enzyme (ACE) is a component of the renin-angiotensin system (RAS), which leads to the conversion of angiotensin-I to angiotensin-II in vascular tissues. The present study aimed to determine serum ACE activity in rats with an aminoglycosine. Material-Method: In this study, two different groups formed, the control group (10 rats/Wistar-albino female) and the experimental group (30 rats/Wistar-albino female) administered aminoglycosine (Amikacin). Aminoglycosine was administered intraperitoneally to the experimental group at a single dose of 15 mg/kg body weight at the same time each day for 14 days. The control group implemented physiological water instead of aminoglycosine at the same rate. Result: When the groups compared according to the statistic results, it is observed that there was a significant increase in the experimental group according to the control group (p˂0.001). Conclusion: As a result, it was determined that aminoglycosin administered increased serum ACE activity and it was concluded that it may be useful to investigate the possibilities to evaluate it as a risk factor and indicator in the development of hypertension

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Bu Makaleye Atıf Yap

YEGİN, S. Ç., DEĞER, Y., DEDE, S., YUR, F. (2021). Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE). Turkish Journal of Veterinary Research, Cilt: 5 - Sayı: 2, 67–71. https://ajindex.com/articles/809767

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Kaynakça (10)

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