Structure determination of the new products (2-5) was established on the basis of IR, 1H NMR, 13C NMR, and mass spectrometry.
📌 3 Maddede Bu Makale
🎯
Amaç & Hipotez:The aim of this research is to synthesize and characterize of new cyclic members of cyclic aminobenzoquinones.
📊
Temel Bulgular & Veri:Mono amino substituted products; 2-chloro-5,6-dimethyl-3-(pyrrolidin-1-yl)-1,4-benzoquinone (2), 2-chloro-5,6-dimethyl-3-(piperidin-1-yl)-1,4-benzoquinone (3), 2-chloro-5,6-dimethyl-3-morpholino-1,4-benzoquinone (4), and 2-chloro-5,6-dimethyl-3-thiomorpholino-1,4-benzoquinone (5) have been synthesized by a green methodology using water as solvent by means of nucleophilic substitution reactions between 2,3-dichloro-5,6-dimethyl-1,4-benzoquinone (1) and cyclic secondary amines.
💡
Sonuç & Katkı:Structure determination of the new products (2-5) was established on the basis of IR, 1H NMR, 13C NMR, and mass spectrometry.
The aim of this research is to synthesize and characterize of new cyclic members of cyclic aminobenzoquinones. Mono amino substituted products; 2-chloro-5,6-dimethyl-3-(pyrrolidin-1-yl)-1,4-benzoquinone (2), 2-chloro-5,6-dimethyl-3-(piperidin-1-yl)-1,4-benzoquinone (3), 2-chloro-5,6-dimethyl-3-morpholino-1,4-benzoquinone (4), and 2-chloro-5,6-dimethyl-3-thiomorpholino-1,4-benzoquinone (5) have been synthesized by a green methodology using water as solvent by means of nucleophilic substitution reactions between 2,3-dichloro-5,6-dimethyl-1,4-benzoquinone (1) and cyclic secondary amines. Structure determination of the new products (2-5) was established on the basis of IR, 1H NMR, 13C NMR, and mass spectrometry.
TUYUN, A. F., YILDIZ, M. (2018). Synthesis and Characterization of New Cyclic Aminobenzoquinones. Journal of the Turkish Chemical Society Section A: Chemistry, Cilt: 5 - Sayı: 2, 371–380. https://ajindex.com/articles/781374
Thomson RH. Distribution of Naturally-Occurring Quinones. Pharm Weekblad. 1991;13(2):70-73
Aly AA, Hassan AA. Heterocycles from Donor-Acceptor Interactions. Adv Heterocycl Chem. 2014;112:145-181
Mbaveng AT, Kuete V, Efferth T. Potential of Central, Eastern and Western Africa Medicinal Plants for Cancer Therapy: Spotlight on Resistant Cells and Molecular Targets. Front Pharmacol. 2017;8.