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Dergiler / Journal of the Turkish Chemical Society Section A: Chemistry / 2022 / Cilt: 9 - Sayı: 2

A Simple Spectrophotometric Determination of Amoxicillin in Drug Samples

Adem ASAN
Nada SEDDIQ
Sayfa
423–432
Yayın Tarihi
2022-05-31
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The standard addition method and statistical parameters were applied to test the accuracy of the proposed method, and the obtained results from the two methods showed good agreement with each other.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In this study, a fast and simple spectrophotometric method was developed for the determination of amoxicillin in drugs without any extraction steps.
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Temel Bulgular & Veri:The developed method is based on the formation of a colored ion pair complex between bromocresol green and amoxycillin in dimethyl sulfoxide-acetonitrile (50 % v/v) medium.
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Sonuç & Katkı:The standard addition method and statistical parameters were applied to test the accuracy of the proposed method, and the obtained results from the two methods showed good agreement with each other.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Amoxicillin · bromine cresol · drug sample

Abstract

In this study, a fast and simple spectrophotometric method was developed for the determination of amoxicillin in drugs without any extraction steps. The developed method is based on the formation of a colored ion pair complex between bromocresol green and amoxycillin in dimethyl sulfoxide-acetonitrile (50 % v/v) medium. The absorbance of the bluish green complex is measured at a wavelength of 630 nm. The factors that affect the ion pair complex formation, such as time, reagent concentration, etc., have been optimized. Under the optimum conditions, the developed method had an average recovery of 98.16% with a relative standard deviation of 3.62 % and showed a very good linear behavior obeying Lambert-Beer's law in the range 1-18 µg mL-1 of amoxycillin concentration. The developed method has been successfully applied to both tablet and powder forms of pharmaceutical preparations. The standard addition method and statistical parameters were applied to test the accuracy of the proposed method, and the obtained results from the two methods showed good agreement with each other.

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Bu Makaleye Atıf Yap

ASAN, A., SEDDIQ, N. (2022). A Simple Spectrophotometric Determination of Amoxicillin in Drug Samples. Journal of the Turkish Chemical Society Section A: Chemistry, Cilt: 9 - Sayı: 2, 423–432. https://ajindex.com/articles/781037

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Kaynakça (12)

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