Amaç & Hipotez:In this study, the electrochemical behaviors of cephalexin and cefazoline on disposable pencil graphite electrode were investigated in phosphate buffer at pH of 4.5 to 6.0 by differential pulse voltammetry.
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Temel Bulgular & Veri:The limits of detection (S/N=3) were found to be 0.115 mM and 0.303 mM, for cephalexin and cefazoline, respectively.
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Sonuç & Katkı:The recovery values were around 100%.
In this study, the electrochemical behaviors of cephalexin and cefazoline on disposable pencil graphite electrode were investigated in phosphate buffer at pH of 4.5 to 6.0 by differential pulse voltammetry. Sample analysis was performed in phosphate buffer at the optimum medium determined for each sample. Validation parameters were studied to show the correctness, sensitivity, and consistency of the method developed for the cephalosporins. It was concluded that disposable pencil graphite electrode could be used effectively in the determination of cephalosporins. The limits of detection (S/N=3) were found to be 0.115 mM and 0.303 mM, for cephalexin and cefazoline, respectively. The analysis of these compounds in pharmaceutical formulations and biological samples was carried out at defined optimum conditions. The recovery values were around 100%.
ÖZKORUCUKLU, S. P., UKA, B., BAŞTEMUR, G. Y. (2019). Voltammetric Analysis of Cephalexin and Cefazoline in Pharmaceutical Formulation and Biological Samples. Journal of the Turkish Chemical Society Section A: Chemistry, Cilt: 6 - Sayı: 2, 217–224. https://ajindex.com/articles/780069
Ierapetritou M, Muzzio F, Reklaitis G. Perspectives on the continuous manufacturing of powder-based pharmaceutical processes. AlChE J. 2016; 62: 1846–62
Bungau S, Suciu R, Bumbu A, Cioca G, Tit DM. Study on hospital waste management in medical rehabilitation clinical hospital, baile felix. J. Environ. Prot. Ecol. 2015; 16: 980–7
Adzitey F. Antibiotic classes and antibiotic susceptibility of bacterial isolates from selected poultry; a mini review. World Vet. J. 2015, 5, 36–41
Watkins Richard R, and Bonomo Robert A. "β-Lactam Antibiotics." Infectious Diseases (Fourth Edition). 2017; 1203-16
Gupta S, Prakash R. Ninety second electrosynthesis of palladium nanocubes on ITO surface and its application in electrosensing of cefotaxime. Electroanalysis 2014; 26: 2337–41
Mokh S, El Khatib M, Koubar M, Daher Z, Al Iskandarani M. Innovative SPE-LC-MS/MS technique for the assessment of 63 pharmaceuticals and the detection of antibiotic-resistant-bacteria: A case study natural water sources in lebanon. Sci. Total Environ. 2017; 609: 830–41
Neves MA, Silva GS, Brito NM, Araujo KCM, Marques EP, Silva LK. Aqueous ultrasound-assisted extraction for the determination of fluoroquinolones in mangrove sediment by high-performance liquid chromatography and fluorescence detector. J. Braz. Chem. Soc. 2018; 29: 24–32
Perez RA, Albero B, Ferriz M, Tadeo JL. Analysis of macrolide antibiotics in water by magnetic solid-phase extraction and liquid chromatography-tandem mass spectrometry. J.Pharm. Biomed. Anal. 2017; 146: 79–85
Dai TT, Duan J, Li XH, Xu XD, Shi HM, Kang WJ. Determination of sulfonamide residues in food by capillary zone electrophoresis with on-line chemiluminescence detection based on an Ag(III) complex. Int. J. Mol. Sci. 2017; 18: 1286-97
Jang MG, Jang MD, Park JH. Doxycycline as a new chiral selector in capillary electrophoresis. J. Chromatogr. A 2017; 1508: 176–81
Moreno-Gonzalez D, Hamed AM, Gilbert-Lopez B, Gamiz-Gracia L, Garcia-Campana AM, Evaluation of a multiresidue capillary electrophoresis-quadrupole-time-of-flight mass spectrometry method for the determination of antibiotics in milk samples. J. Chromatogr. A 2017; 1510: 100–7
Bitas D, Samanidou VF, Effective cleanup for the determination of six quinolone residues in shrimp before HPLC with diode array detection in compliance with the European Union Decision 2002/657/EC. J. Sep. Sci. 2016; 39: 4805–11
Samanidou V, Michaelidou K, Kabir A, Furton KG. Fabric ph