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Dergiler / Journal of Surgery and Medicine / 2021 / Cilt: 5 - Sayı: 9

Investigation of the effect of anti-epileptic drugs on bone metabolism using osteoprotegerin and bone-specific alkaline phosphatase: The direct effects of antiepileptic drugs on bone metabolism

Buket TUĞAN YILDIZ
Tuba Tülay KOCA
Muhammed SEYİTHANOĞLU
Duygun ALTINTAŞ AYKAN
Sayfa
974–977
Yayın Tarihi
2021-09-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Male patients, females who were

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Background/Aim: Anti-epileptic drugs are long-term medications; thus, side-effects are frequently seen.
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Temel Bulgular & Veri:The mechanism of this entity is not clearly known, but it is usually seen with the use of cytochrome P450 enzyme-inducing anti-epileptics.
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Sonuç & Katkı:Male patients, females who were
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Antiepileptic drugs · Metabolic bone disease · Osteoporosis

Abstract

Background/Aim: Anti-epileptic drugs are long-term medications; thus, side-effects are frequently seen. An important but insufficiently known side-effect is the emergence of metabolic bone diseases. The mechanism of this entity is not clearly known, but it is usually seen with the use of cytochrome P450 enzyme-inducing anti-epileptics. However, recent studies demonstrated that non-enzyme-inducing molecules also cause bone mineral impairment. The aim of this study was to shed light on the pathogenesis of anti-epileptic metabolic bone disease using bone turnover markers. Methods: This comparative, prospective case-control study included 37 patients followed-up in our outpatient clinic and 39 healthy control subjects. All the patients were female, aged over 18 years and in the premenopausal period, and had received the same anti-epileptic treatment for at least 3 months. Male patients, females who were

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YILDIZ, B. T., KOCA, T. T., SEYİTHANOĞLU, M., AYKAN, D. A. (2021). Investigation of the effect of anti-epileptic drugs on bone metabolism using osteoprotegerin and bone-specific alkaline phosphatase: The direct effects of antiepileptic drugs on bone metabolism. Journal of Surgery and Medicine, Cilt: 5 - Sayı: 9, 974–977. https://ajindex.com/articles/779860

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Kaynakça (9)

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