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Dergiler / Journal of the Turkish Chemical Society Section A: Chemistry / 2019 / Cilt: 6 - Sayı: 2

Synthesis, E/Z isomerisation and antimicrobial studies of different structured novel ketone derivatives.

Aysema SAYIK MEHAN
Ebru SENTURK
Emel MATARACI KARA
Ayse Serguzel YUSUFOGLU
Sayfa
177–188
Yayın Tarihi
2019-06-15
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Besides, acetyl acetone as a diketone delivered the known 1-(2,4-dinitrophenyl)-3,5-dimethyl-1H-pyrazole (p1) which showed very high antimicrobial activity than hydrazones and semicarbazones against Klebsiella pneumoniae ATCC 4352, Proteus mirabilis ATCC 14153, Staphylococcus epidermidis ATCC 12228, Enterococcus faecalis ATCC 29212, Candida parapsilosis ATCC 22019, Candida tropicalis ATCC 750.

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Amaç & Hipotez:In this study five different structured mono ketones’ (k1- k5) novel derivatives as five new hydrazones (h1-h5) and five new semicarbazones (s1-s5) were synthesized.
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Temel Bulgular & Veri:The synthesized compounds were identified by IR, 1H-NMR, 13C-NMR, mass and chromatographic methods for their structures and E/Z isomerizations.
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Sonuç & Katkı:Besides, acetyl acetone as a diketone delivered the known 1-(2,4-dinitrophenyl)-3,5-dimethyl-1H-pyrazole (p1) which showed very high antimicrobial activity than hydrazones and semicarbazones against Klebsiella pneumoniae ATCC 4352, Proteus mirabilis ATCC 14153, Staphylococcus epidermidis ATCC 12228, Enterococcus faecalis ATCC 29212, Candida parapsilosis ATCC 22019, Candida tropicalis ATCC 750.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Diazo compounds · Substituent effect · Heterocycles

Abstract

In this study five different structured mono ketones’ (k1- k5) novel derivatives as five new hydrazones (h1-h5) and five new semicarbazones (s1-s5) were synthesized. The synthesized compounds were identified by IR, 1H-NMR, 13C-NMR, mass and chromatographic methods for their structures and E/Z isomerizations. These mentioned hydrazones and semicarbazones were investigated for their antimicrobial activities. Seven bacterias and three fungis were tested. Ciprofloxacin and Fluconazole were used as standards. MIC values were determined. The relationship between structure and antimicrobial actvity was discussed. Hydrazones were more effective than semicarbazones. Besides, acetyl acetone as a diketone delivered the known 1-(2,4-dinitrophenyl)-3,5-dimethyl-1H-pyrazole (p1) which showed very high antimicrobial activity than hydrazones and semicarbazones against Klebsiella pneumoniae ATCC 4352, Proteus mirabilis ATCC 14153, Staphylococcus epidermidis ATCC 12228, Enterococcus faecalis ATCC 29212, Candida parapsilosis ATCC 22019, Candida tropicalis ATCC 750.

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Bu Makaleye Atıf Yap

MEHAN, A. S., SENTURK, E., KARA, E. M., YUSUFOGLU, A. S. (2019). Synthesis, E/Z isomerisation and antimicrobial studies of different structured novel ketone derivatives.. Journal of the Turkish Chemical Society Section A: Chemistry, Cilt: 6 - Sayı: 2, 177–188. https://ajindex.com/articles/779359

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