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Dergiler / Journal of Ongoing Chemical Research / 2017 / Cilt: 3 - Sayı: 1

SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES

Yusuf SICAK
Said NADEEM
Bedriye Seda Kurşun AKTAR
Emine Elçin ORUÇ EMRE
Mehmet ÖZTÜRK
Ayşegül Karaküçük İYİDOĞAN
Mehmet Ali ÖZLER
İbrahim DEMİRTAŞ
Sayfa
32–49
Yayın Tarihi
2017-06-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

According to tyrosinase assay results, compound 2f showed the good tyrosinase inhibitory activity i.e. 6.12±0.40 mM of IC50

📌 3 Maddede Bu Makale

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Amaç & Hipotez:A series of some pyrazolo derivatives a-f were synthesized and their urease inhibitory and tyrosinase inhibitory activities were evaluated.
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Temel Bulgular & Veri:Among synthesized compounds, 2f, 2e, 1f, 2d, 1e, 2b, and 1d showed excellent activities IC50 i.e. 11.73±0.28, 14.21±0.56, 15.37±0.89, 17.66±0.82, 18.64±0.19, 19.55±0.39, and 22.08±0.96 µM, respectively.
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Sonuç & Katkı:According to tyrosinase assay results, compound 2f showed the good tyrosinase inhibitory activity i.e. 6.12±0.40 mM of IC50
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Pyrrolidine · chiral · thiazolidine-2

Abstract

A series of some pyrazolo derivatives a-f were synthesized and their urease inhibitory and tyrosinase inhibitory activities were evaluated. Among synthesized compounds, 2f, 2e, 1f, 2d, 1e, 2b, and 1d showed excellent activities IC50 i.e. 11.73±0.28, 14.21±0.56, 15.37±0.89, 17.66±0.82, 18.64±0.19, 19.55±0.39, and 22.08±0.96 µM, respectively. According to tyrosinase assay results, compound 2f showed the good tyrosinase inhibitory activity i.e. 6.12±0.40 mM of IC50

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Bu Makaleye Atıf Yap

SICAK, Y., NADEEM, S., AKTAR, B. S. K., EMRE, E. E. O., ÖZTÜRK, M., İYİDOĞAN, A. K., ÖZLER, M. A., DEMİRTAŞ, İ. (2017). SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES. Journal of Ongoing Chemical Research, Cilt: 3 - Sayı: 1, 32–49. https://ajindex.com/articles/778198

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