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Dergiler / Journal of Health Sciences and Medicine / 2021 / Cilt: 4 - Sayı: 6

Dapsone can be a new treatment option for reducing the detrimental effect of priapism

Engin KÖLÜKÇÜ
Bekir Süha PARLAKTAŞ
Nihat ULUOCAK
Faik DERESOY
Velid UNSAL
Muzaffer KATAR
Sayfa
800–808
Yayın Tarihi
2021-09-24
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The highest values of malondialdehyde (MDA), protein carbonyl (PC) and total oxidant status (TOS) were recorded in Group 2 (p

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Aim: This study aims to analyze the effect of dapsone against ischaemia-reperfusion injury on corporal tissue in a model of induced-priapism in rats.
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Temel Bulgular & Veri:Material and Method: A total of 24 rats were randomized into three groups.
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Sonuç & Katkı:The highest values of malondialdehyde (MDA), protein carbonyl (PC) and total oxidant status (TOS) were recorded in Group 2 (p
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Dapsone · priapism · ischaemia reperfusion injury

Abstract

Aim: This study aims to analyze the effect of dapsone against ischaemia-reperfusion injury on corporal tissue in a model of induced-priapism in rats. Material and Method: A total of 24 rats were randomized into three groups. Group 1 was defined as the control group. Ischaemia-reperfusion injury was evaluated following the priapism model in Group 2. Group 3 had similar procedures to the rats in Group 2. Group 3 additionally had 12.5 mg/kg dapsone administered intraperitoneally 30 minutes after priapism. Results: Biochemical analysis of blood indicated a significant increase in Group 3 in terms of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity and total antioxidant status (TAS) values compared with Group 2 (p:0.002, p:0.029 and p:0.009, respectively). The highest values of malondialdehyde (MDA), protein carbonyl (PC) and total oxidant status (TOS) were recorded in Group 2 (p

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Bu Makaleye Atıf Yap

KÖLÜKÇÜ, E., PARLAKTAŞ, B. S., ULUOCAK, N., DERESOY, F., UNSAL, V., KATAR, M. (2021). Dapsone can be a new treatment option for reducing the detrimental effect of priapism. Journal of Health Sciences and Medicine, Cilt: 4 - Sayı: 6, 800–808. https://ajindex.com/articles/776721

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Kaynakça (14)

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