Dergiler / Journal of Contemporary Medicine / 2019 / Cilt: 9 - Sayı: 4

Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience

Sayfa
359–364
Yayın Tarihi
2019-12-31
DOI
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Though, results obtained here are similar to those of national and international studies.

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Amaç & Hipotez:AbstractAim: Analysis of the data of children following stem cell transplantation.Materials and Methods: A total of 44 children who received stem cell transplant between February 2009 and May 2011 were evaluated retrospectively.
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Temel Bulgular & Veri:Results: Among the patients with a mean age of 9.6 ± 4.63 years, 20 (45.5%) were male, whereas 24 (54.5%) were female.
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Sonuç & Katkı:Though, results obtained here are similar to those of national and international studies.
🔬Tür:Araştırma Makalesi
📍Kapsam:2009 Verileri
⚙️Değişkenler:Hematopoietic stem cell transplantation · prognosis · transplant-related mortality

Abstract

AbstractAim: Analysis of the data of children following stem cell transplantation.Materials and Methods: A total of 44 children who received stem cell transplant between February 2009 and May 2011 were evaluated retrospectively. Results: Among the patients with a mean age of 9.6 ± 4.63 years, 20 (45.5%) were male, whereas 24 (54.5%) were female. The initial diagnosis of the patients with decreasing order of frequency was as follows: thalassemia major (n=15), acute leukemia (n=9), Fanconi aplastic anemia (n=6), aplastic anemia (n=5) and other disorders (n=9). Disease-free survival in two years was observed in 27 (61.3%) of patients. Relapse occurred in 8 (18.1%) patients, whereas 9 (20.4%) patients died. The mortality was transplant-related in two cases, whereas it was due to progression of the underlying disease in 7 (15.9%) patients. Conclusion: As the stem cell transplantation has become widespread in Türkiye recently, its data are valuable. We found high incidence of mucositis and infection due to myeloablative regimens. The limitation of our study is the small number of patients included. Though, results obtained here are similar to those of national and international studies.

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Bu Makaleye Atıf Yap

GÜNGÖRER, V., KESKİN, E. Y., FIŞGIN, T. (2019). Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience. Journal of Contemporary Medicine, Cilt: 9 - Sayı: 4, 359–364. https://ajindex.com/articles/775224

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Kaynakça (15)

  1. Gluckman E, Gratwohl A, Apperley J. The EBMT Handbook. In: J Apperley, E Carreras, E Gluckman, A Gratwohl, T Masszi, editors. Hematopoietic stem cell transplantation for primary amyloidosis in adult (5th ed), France 2008, pp. 424
  2. EBMT criteria, form MED-A 2007
  3. Allen RD, Staley TA, Sidman CL. Differential cytokine expression in acute and chronic murine graft- versus-host-disease. Eur J Immunol 1993; 23(2): 333-37
  4. Ogawa M. Differentiation and Proliferation of Hematopoietic Stem Cells. Blood 1993; 81(11):2844-53
  5. McDonald GB, Hinds MS, Fisher LD, et al. Venoocclusive disease of the liver and multiorgan failure after bone marrow transplantation a cohort study of 355 patients. Ann Intern Med 1993;118(4): 255–67
  6. Kansoy S. TPHD 9. Ulusal Pediatrik Hematoloji Kongresi Van 24-28 mayıs 2013
  7. Miano M, Labopin M, Hartman O, et al. Haematopoietic stem cell transplantation trends in children over the last three decades: a survey by the paediatric diseases woking party of the Europan Group for Blood and Marrow Transplantation. Bone Marrow Transplant 2007; 39: 89-99
  8. Körbling M, Freireich EJ. Twenty five years of peripheral blood stem cell transplantation. Blood.2011; 117(24): 6411-6.9) Gluckman E, Broxmeyer HA, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical cord-blood from HLH-identical sibling.N Eng J Med 1989; 321(17):1174-8
  9. Kansoy S. Ulusal Pediatrik HKHT Aktivitesinin Değerlendirilmesi. Ege Üniversitesi Tıp Fakültesi, Pediyatrik KİT Ünitesi, TPHD KİT veritabanı, TPHD KİT Çalışma Grubu
  10. Ulusal Kemik İliği Transplantasyonu Ve Kök Hücre Tedavileri Kongresi 2014
  11. Thissiane L Gonçalves, Dalila M Benvegnú, Gabriela Bonfanti. Specific factors influence the success of autologous and allogeneic hematopoietic stem cell transplantation. Oxid Med Cell Longev 2009; 2(2): 82-87
  12. Beşışık S.K, Ülkemizde akraba dışı allogenik hematopoetik hücre nakli deneyimi
  13. Ulusal Kemik İliği Transplantasyonu ve Kök Hücre Tedavileri Kongresi Bildiri Özetleri, Bursa, 2007 s76
  14. Engels E.A, Ellis C.A, Supran S.E, et al. Early Infection in Bone Marrow Transplantation: Quantitative Study of Clinical Factors That Affect Risk. Clinical Infectious Diseases 1999; 28 (2): 256- 266
  15. Krüger W.H, Boblins J, Kornely O.A, et al. Antimicrobial prophylaxis in allogeneic bone marrow transplantation. Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Onc