In this study, the effect of pesticides on the enzyme activity of Aldose reductase (AR) (EC 1.1.1.21), which is involved in polyol pathway and detoxification reactions, has been investigated.For this purpose, AR enzyme was purified from chicken liver and the IC50 values were plotted as % Activity-[I] for pesticides with inhibition effect and The maximum inhibitory effect was determined at 2,4,5-T with 162μM.
📌 3 Maddede Bu Makale
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Amaç & Hipotez:In this study, the effect of pesticides on the enzyme activity of Aldose reductase (AR) (EC 1.1.1.21), which is involved in polyol pathway and detoxification reactions, has been investigated.For this purpose, AR enzyme was purified from chicken liver and the IC50 values were plotted as % Activity-[I] for pesticides with inhibition effect and The maximum inhibitory effect was determined at 2,4,5-T with 162μM.
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Temel Bulgular & Veri:In this study, the effect of pesticides on the enzyme activity of Aldose reductase (AR) (EC 1.1.1.21), which is involved in polyol pathway and detoxification reactions, has been investigated.For this purpose, AR enzyme was purified from chicken liver and the IC50 values were plotted as % Activity-[I] for pesticides with inhibition effect and The maximum inhibitory effect was determined at 2,4,5-T with 162μM.
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Sonuç & Katkı:In this study, the effect of pesticides on the enzyme activity of Aldose reductase (AR) (EC 1.1.1.21), which is involved in polyol pathway and detoxification reactions, has been investigated.For this purpose, AR enzyme was purified from chicken liver and the IC50 values were plotted as % Activity-[I] for pesticides with inhibition effect and The maximum inhibitory effect was determined at 2,4,5-T with 162μM.
In this study, the effect of pesticides on the enzyme activity of Aldose reductase (AR) (EC 1.1.1.21), which is involved in polyol pathway and detoxification reactions, has been investigated.For this purpose, AR enzyme was purified from chicken liver and the IC50 values were plotted as % Activity-[I] for pesticides with inhibition effect and The maximum inhibitory effect was determined at 2,4,5-T with 162μM.
Straathof, A. J.; Panke, S.; Schmid, A., The production of fine chemicals by biotransformations. Current opinion in biotechnology 2002, 13, (6), 548-556.2. Pollard, D. J.; Woodley, J. M., Biocatalysis for pharmaceutical intermediates: the future is now. TRENDS in Biotechnology 2007, 25, (2), 66-73.3. Şengül, B.; Beydemir, Ş., The interactions of cephalosporins on polyol pathway enzymes from sheep kidney. Archives of physiology and biochemistry 2018, 124, (1), 35-44.