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Dergiler / Türk Doğa ve Fen Dergisi / 2022 / Cilt: 11 - Sayı: 3

Evaluation of the Biological Activities of Royal Jelly on Prostate and Breast Cancer Cells

Adnan AYNA
Ekrem DARENDELİOĞLU
Sayfa
166–170
Yayın Tarihi
2022-09-29
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

According to the data of this research, RJ act as prooxidants in PC-3 and MCF-7 cancer cell lines by lessening cellular viability and raising ROS and LPO formation.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Due to their high toxicity to healthy body cells, chemotherapy drugs used to treat cancer pose a serious threat to the organism.
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Temel Bulgular & Veri:However, RJ's cytotoxic and antioxidant properties on PC-3 prostate cancer and MCF-7 breast cancer cell lines have yet to be thoroughly investigated at the cellular level.
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Sonuç & Katkı:According to the data of this research, RJ act as prooxidants in PC-3 and MCF-7 cancer cell lines by lessening cellular viability and raising ROS and LPO formation.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Royal jelly · WST-1 Assay · Prostate cancer

Abstract

Due to their high toxicity to healthy body cells, chemotherapy drugs used to treat cancer pose a serious threat to the organism. Recent studies have encouraged the utilization of bee products to prevent and treat the cancer. The specific food for the queen honeybee larva (Apis mellifera), royal jelly (RJ) is a yellow, milky, cremy product of the bee which is stowed from the mandibular and hypopharyngeal glands of the worker honeybee. According to the reports, RJ may have cytotoxic effects in animal models. However, RJ's cytotoxic and antioxidant properties on PC-3 prostate cancer and MCF-7 breast cancer cell lines have yet to be thoroughly investigated at the cellular level. Therefore, the antioxidant and anti-proliferative activities of RJ in PC-3 prostate cancer cells and MCF-7 breast cancer cells were evaluated to investigate a chemopreventive strategy to increase cancer therapy efficacy. WST-1 assay was used to measure cell proliferation, and levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) were analyzed to look at antioxidant activities. According to the data of this research, RJ act as prooxidants in PC-3 and MCF-7 cancer cell lines by lessening cellular viability and raising ROS and LPO formation.

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Bu Makaleye Atıf Yap

AYNA, A., DARENDELİOĞLU, E. (2022). Evaluation of the Biological Activities of Royal Jelly on Prostate and Breast Cancer Cells. Türk Doğa ve Fen Dergisi, Cilt: 11 - Sayı: 3, 166–170. https://ajindex.com/articles/705683

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  1. Filipič B, Gradišnik L, Rihar K, Šooš E, Pereyra A, Potokar J (2015). The influence of royal jelly and human interferon-alpha (HuIFN-αN3) on proliferation, glutathione level and lipid peroxidation in human colorectal adenocarcinoma cells in vitro. Arhiv Za Higijenu Rada i Toksikologiju, 66 (4): 269-274. doi: 10.1515/aiht-2015-66-2632 [2] Ramanathan ANKG, Nair AJ, Sugunan VS (2018). A review on Royal Jelly proteins and peptides. Journal of Functional Foods 44: 255-264. doi: 10.1016/j.jff.2018.03.008 [3] Dobritzsch D, Aumer D, Fuszard M, Erler S, Buttstedt A (2019). The rise and fall of major royal jelly proteins during a honeybee (Apis mellifera) workers’ life. Ecology and Evolution 9 (15): 8771-8782. doi: 10.1002/ece3.5429 [4] Coutinho D, Karibasappa SN, Mehta DS (2018). Royal jelly antimicrobial activity against periodontopathic bacteria. Journal of Interdisciplinary Dentistry 8 (1): 18. doi: 10.4103/ jid.jid_72_17 Darendelioglu, E (2020). Neuroprotective effects of chrysin on diclofenac-induced apoptosis in SH-SY5Y cells. Neurochemical Research 45 (5): 1064-1071. doi: 10.1007/s11064-020-02982-8. [5] Park HG, Kim BY, Park MJ, Deng Y, Choi YS et al. (2019). Antibacterial activity of major royal jelly proteins of the honeybee (Apis mellifera) royal jelly. Journal of Asia-Pacific Entomology 22 (3): 737-741. doi: 10.1016/j.aspen.2019.06.005 [6] Ahmad S, Campos MG, Fratini F. Altaye SZ, Li J (2020). New insights into the biological and pharmaceutical properties of royal jelly. International Journal of Molecular Sciences 21 (2): 382- 407. doi: 10.3390/ijms21020382 [7] Park MJ, Kim BY, Deng Y, Park HG, Choi YS et al. (2020). Antioxidant capacity of major royal jelly proteins of honeybee (Apis mellifera) royal jelly. Journal of Asia-Pacific Entomology, 23 (2): 445-448. doi: 10.1016/j.aspen.2020.03.007 [8] Guo J, Wang Z, Chen Y, Cao J, Tian W et al. (2021). Active components and biological functions of royal jelly. Journal of Functional Foods 82: 104514. doi: 10.1016/j.jff.2021.104514 [9] Lercker G, Capella P, Conte LS, Ruini F, Giordani G (1981). Components of royal jelly: I. Identification of the organic acids. Lipids 16 (12): 912-919. doi:10.1007/BF02534997 [10] Viuda‐Martos M, Ruiz‐Navajas Y, Fernández‐López J, Pérez‐Álvarez JA (2008). Functional properties of honey, propolis, and royal jelly. Journal of Food Science 73 (9): 117-124. doi:10.1111/ j.1750-3841.2008.00966.x [11] Pasupuleti VR, Sammugam L, Ramesh N, Gan SH (2017). Honey, propolis, and royal je