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Dergiler / Ulusal Travma ve Acil Cerrahi Dergisi / 2022 / Cilt: 28 - Sayı: 6

The protective effect of roflumilast and ibuprofen on testicular ischemia reperfusion injury: An experimental study

Berat Cem Özgür
Hatice Sürer
Cem Nedim Yücetürk
Tolga Karakan
Elif Özer
Elmas Öğüş
Sayfa
730–735
Yayın Tarihi
2022-11-07
DOI
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RESULTS: Tissue MPO, MDA, and NO levels were significantly higher and TSH levels significantly lower in control group compared to sham group (p

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Amaç & Hipotez:BACKGROUND: The aim of the present study is to investigate the efficiency of roflumilast and ibuprofen in an experimental rat testicular ischemia reperfusion injury model in the light of histological and biochemical data.
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Temel Bulgular & Veri:METHODS: A total of 32 prepubertal male rats were randomly divided into four groups as G1: Control Group (testicular torsion/ detorsion + saline (0.9% of 2 ml) was applied).
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Sonuç & Katkı:RESULTS: Tissue MPO, MDA, and NO levels were significantly higher and TSH levels significantly lower in control group compared to sham group (p
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

BACKGROUND: The aim of the present study is to investigate the efficiency of roflumilast and ibuprofen in an experimental rat testicular ischemia reperfusion injury model in the light of histological and biochemical data. METHODS: A total of 32 prepubertal male rats were randomly divided into four groups as G1: Control Group (testicular torsion/ detorsion + saline (0.9% of 2 ml) was applied). G2: Sham Group only right scrotal incision was performed; G3: Ibuprofen Group (tes- ticular torsion/detorsion + ibuprofen administration); and G4 Roflumilast Group (testicular torsion/detorsion + roflumilast adminis- tration). Oxidative markers such as malondialdehyde (MDA), myeloperoxidase (MPO), total sulfhydryl (TSH), and nitrite (NO) levels as well as histopathological changes were analyzed. RESULTS: Tissue MPO, MDA, and NO levels were significantly higher and TSH levels significantly lower in control group compared to sham group (p

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Bu Makaleye Atıf Yap

Özgür, B. C., Sürer, H., Yücetürk, C. N., Karakan, T., Özer, E., Öğüş, E. (2022). The protective effect of roflumilast and ibuprofen on testicular ischemia reperfusion injury: An experimental study. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 28 - Sayı: 6, 730–735. https://ajindex.com/articles/655407

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Kaynakça (12)

  1. Pogorelić Z, Mrklić I, Jurić I. Do not forget to include testicular torsion in differential diagnosis of lower acute abdominal pain in young males. J Pediatr Urol 2013;9:1161–5
  2. Pogorelić Z, Mustapić K, Jukić M, Todorić J, Mrklić I, Mešštrović J, et al. Management of acute scrotum in children: A 25-year single center expe- rience on 558 pediatric patients. Can J Urol 2016;23:8594–601
  3. Moghimian M, Soltani M, Abtahi H, Adabi J, Jajarmy N. Protective effect of tunica albuginea incision with tunica vaginalis flap coverage on tissue damage and oxidative stress following testicular torsion: Role of duration of ischemia. J Pediatr Urol 2016;12:390.e1–6
  4. Mogilner JG, Elenberg Y, Lurie M, Shiloni E, Coran AG, Sukhotnik I. Effect of dexamethasone on germ cell apoptosis in the contralateral testis after testicular ischemia-reperfusion injury in the rat. Fertil Steril 2006;85 Suppl 1:1111–7
  5. Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A. Spermatic cord torsion, reactive oxygen and nitrogen species and ischemi- a-reperfusion injury. Mol Aspects Med 2004;25:199–210
  6. Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression. Proc Natl Acad Sci U S A 2002;99:13926–31
  7. Lau C, Mehta AC, Hatipoglu U. What is the role of roflumilast in chronic obstructive pulmonary disease? Cleve Clin J Med 2017;84:13–5
  8. Keseroglu BB, Ozgur BC, Surer H, Ogus E, Hucemenoglu S, Ozer E, et al. Which agent should be used to reduce ischemia-reperfusion injury after testicular torsion: A comparative animal experiment. J Pediatr Urol 2019;15:607.e1–7
  9. Dokmeci D, Kanter M, Inan M, Aydogdu N, Basaran UN, Yalcin O, et al. Protective effects of ibuprofen on testicular torsion/detorsion-induced ischemia/reperfusion injury in rats. Arch Toxicol 2007;81:655–63
  10. Ansari MN, Ganaie MA, Rehman NU, Alharthy KM, Khan TH, Imam F, et al. Protective role of Roflumilast against cadmium-induced car- diotoxicity through inhibition of oxidative stress and NF-κB signaling in rats. Saudi Pharm J 2019;27:673–81
  11. Wasowicz W, Nève J, Peretz A. Optimized steps in fluorometric deter- mination of thiobarbituric acid-reactive substances in serum: İmportance of extraction pH and influence of sample preservation and storage. Clin Chem 1993;39:2522–6
  12. Smárason AK, Allman KG, Young D, Redman CW. Elevated levels of serum nitrate