KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Biology / 2016 / Cilt: 40 - Sayı: 5

Pluripotent stem cells and their use in hearing loss

Mustafa Yavuz KÖKER
Ahmet Hamdi KEPEKÇİ
Okan Özgür ÖZTURAN
Sayfa
1033–1039
Yayın Tarihi
2022-11-05
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Cellular treatment and regenerative medicine with pluripotent cells are currently developing and we aimed to raise awareness about this topic in our paper on using iPS cell technology in the biological treatment of hearing loss, which is an important area of research in otolaryngology.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Throughout its half a century of development, stem cell research has included two main fields: embryonic stem (ES) cell research and the reprogramming of body somatic cells.
📊
Temel Bulgular & Veri:The human body somatic cells are transformed into pluripotent cells by three basic methods: the somatic nuclear transfer method, the somatic cell fusion method (getting cellular pluripotent capacity in cellular reprogramming), and by transcription factors influencing the body somatic cells to generate reprogrammed induced pluripotent stem (iPS) cells.
💡
Sonuç & Katkı:Cellular treatment and regenerative medicine with pluripotent cells are currently developing and we aimed to raise awareness about this topic in our paper on using iPS cell technology in the biological treatment of hearing loss, which is an important area of research in otolaryngology.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Throughout its half a century of development, stem cell research has included two main fields: embryonic stem (ES) cell research and the reprogramming of body somatic cells. In the present review we focused on stem cell reprogramming and its relation with otolaryngology. The human body somatic cells are transformed into pluripotent cells by three basic methods: the somatic nuclear transfer method, the somatic cell fusion method (getting cellular pluripotent capacity in cellular reprogramming), and by transcription factors influencing the body somatic cells to generate reprogrammed induced pluripotent stem (iPS) cells. ES cells and iPS cells have pluripotency and differentiate into cells originating from the three germ layers; they are preferred for cellular treatment, drug development, and disease modeling research. Because of ethical restrictions in obtaining ES cells, iPS cells are an alternative pluripotent cell source and patient-specific autologous pluripotent cells are obtained by this method. Cellular treatment and regenerative medicine with pluripotent cells are currently developing and we aimed to raise awareness about this topic in our paper on using iPS cell technology in the biological treatment of hearing loss, which is an important area of research in otolaryngology.

🔖

Bu Makaleye Atıf Yap

KÖKER, M. Y., KEPEKÇİ, A. H., ÖZTURAN, O. Ö. (2022). Pluripotent stem cells and their use in hearing loss. Turkish Journal of Biology, Cilt: 40 - Sayı: 5, 1033–1039. https://ajindex.com/articles/654440

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (15)

  1. Bayart E, Cohen-Haguenauer O (2013). Technological overview of iPS induction from human adult somatic cells. Curr Gene Ther 13: 73-92.
  2. Bermingham-McDonogh O, Reh TA (2011). Regulated reprogramming in the regeneration of sensory receptor cells. Neuron 71: 389-405.
  3. Brigande JV, Heller S (2009). Quo vadis, hair cell regeneration? Nat Neurosci 12: 679-685.
  4. Diekman BO, Christoforou N, Willard VP, Sun H (2012). Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells. P Natl Acad Sci USA 109: 19172-19177.
  5. Evans MJ, Kaufman MH (1981). Establishment in culture of pluripotent tail cells from Mouse embryos. Nature 292: 154-156.
  6. Flynn R, Grundmann A, Renz P, Hänseler W, James WS, Cowley SA, Moore MD, 2015. CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells. Exp Hematol 43: 838-848.
  7. Gonzalez F, Boue S, Izpisua Belmonte JC (2011). Methods for making induced pluripotent stem cells: reprogramming a la carte. Nat Rev Genet 12: 231-242.
  8. Grskovic M, Javaherian A, Strulovici B, Daley GQ (2011). Induced pluripotent stem cells-opportunities for disease modelling and drug discovery. Nat Rev Drug Discov 10: 915-929.
  9. Gurdon JB, Elsdale TR, Fischberg M (1958). Sexually mature individuals of Xenopus laevis from the transplantation of single somatic nuclei. Nature 182: 64-65.
  10. Horii T, Hatada I (2011). Reprogrammed parthenogenetic ES cells-new choice for regenerative medicine. In: Atwood C, editor. Methodological Advances in the Culture Manipulation and Utilization of Embryonic Stem Cells for Basic and Practical Applications. Rijeka, Croatia: InTech, pp. 221-236.
  11. Hu Z, Ulfendahl M (2013). The potential of stem cells for the restoration of auditory function in humans. Regen Med 8: 309-318.
  12. Ilic D, Polak JM (2011). Stem cells in regenerative medicine: introduction. Brit Med Bull 98: 117-126.
  13. Jansson L, Kim GS, Cheng AG (2015). Making sense of Wnt signaling-linking hair cell regeneration to development. Front Cell Neurosci 9: 66. Kaufman MH, Robertson EJ, Handyside AH, Evans MJ (1983). Establishment of pluripotential cell lines from haploid mouse embryos. J Embryol Exp Morph 73: 249-261.Koehler KR, Mikosz AM, Molosh AI, Patel D (2013). Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture. Nature 500: 217-221.
  14. Kolios G, Moodley Y (2013). Introduction to stem cells and regenerative medicine. Respiration 85: 3-10.
  15. Liu Y, Ye X, Mao L, Cheng Z (2013). Transplan