KaydedilenlerDerginizi ekleyin

Dergiler / Turkish Journal of Biology / 2017 / Cilt: 41 - Sayı: 2

The comparison of antioxidant capacity and cytotoxic, anticarcinogenic, and genotoxic effects of Fe@Au nanosphere magnetic nanoparticles

Adem ZENGİN
İsmail Hakkı BOYACI
Uğur TAMER4
Hande YEĞENOĞLU
Belma ASLIM
Zekiye SULUDERE
Burcu GÜVEN
Sayfa
302–313
Yayın Tarihi
2022-11-05
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The genotoxic effects of nanoparticles were also evaluated with DNA tail damage ratio.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Magnetic gold nanoparticles are used in various biomedical, biochemistry, and biotechnology applications due to their controllable size distribution, long-term stability, reduced toxicity, and biocompatibility.
📊
Temel Bulgular & Veri:Different coating materials, such as proteins, carbohydrates, lipids, and polyphenols, are applied to enhance the biocompatibility of nanoparticles.
💡
Sonuç & Katkı:The genotoxic effects of nanoparticles were also evaluated with DNA tail damage ratio.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Magnetic gold nanoparticles are used in various biomedical, biochemistry, and biotechnology applications due to their controllable size distribution, long-term stability, reduced toxicity, and biocompatibility. Different coating materials, such as proteins, carbohydrates, lipids, and polyphenols, are applied to enhance the biocompatibility of nanoparticles. In this study, the effects of surface coatings of core-shell structured Fe@Au nanosphere magnetic nanoparticles with regard to antioxidant capacity and cytotoxic, anticarcinogenic, and genotoxic properties were investigated. The obtained results demonstrated that avidin-coated Fe@Au nanospheres had higher antioxidant capacities than uncoated nanospheres. Neither avidin-coated nor uncoated nanoparticles had a cytotoxic effect on normal cells (human gingival fibroblast cell line, HGF-1). In addition, they had anticarcinogenic effects on human cervical carcinoma (HeLa), human breast adenocarcinoma (MCF-7), and human colorectal adenocarcinoma (CCL-221). The genotoxic effects of nanoparticles were also evaluated with DNA tail damage ratio.

🔖

Bu Makaleye Atıf Yap

ZENGİN, A., BOYACI, İ. H., TAMER4, U., YEĞENOĞLU, H., ASLIM, B., SULUDERE, Z., GÜVEN, B. (2022). The comparison of antioxidant capacity and cytotoxic, anticarcinogenic, and genotoxic effects of Fe@Au nanosphere magnetic nanoparticles. Turkish Journal of Biology, Cilt: 41 - Sayı: 2, 302–313. https://ajindex.com/articles/654415

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (13)

  1. Ada K, Turk M, Oguztuzun S, Kilic M, Demirel M, Tandogan N, Ersayar E, Latif O (2010). Cytotoxicity and apoptotic effects of nickel oxide nanoparticles in cultured HeLa cells. Folia Histochem Cyto 48: 524-529.
  2. Amin ML, Joo JY, Yi DK, An SSA (2015). Surface modification and local orientations of surface molecules in nanotherapeutics. J Control Release 207: 131-142.
  3. Andreu-Navarro A, Fernandez-Romero JM, Gomez-Hens A (2011). Determination of antioxidant additives in foodstuffs by direct measurement of gold nanoparticle formation using resonance light scattering detection. Anal Chim Acta 695: 11-17.
  4. Blois MS (1958). Antioxidant determinations by the use of a stable free radical. Nature 181: 1199-1200.
  5. Cekic SD, Demir A, Baskan KS, Tutem E, Apak R (2015). Determination of total antioxidant capacity of milk by CUPRAC and ABTS methods with separate characterisation of milk protein fractions. J Dairy Res 82: 177-184.
  6. Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M (2005). Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a prodrug to deliver hydrogen peroxide to tissues. P Natl Acad Sci USA 102: 13604-13609.
  7. Chen YS, Hung YC, Liau I, Huang GS (2009). Assessment of the in vivo toxicity of gold nanoparticles. Nanoscale Res Lett 4: 858- 864. Clutton S (1997). The importance of oxidative stress in apoptosis. Brit Med Bull 53: 662-668.
  8. Flora SJS, Dikshit M, Flora G (2007). Role of free radicals and antioxidants in health and disease. Cell Mol Biol 53: 1-3.
  9. Fujita T, Nishikawa M, Ohtsubo Y, Ohno J, Takakura Y, Sezaki H, Hashida M (1994). Control of in-vivo fate of albumin derivatives utilizing combined chemical modification. J Drug Target 2: 157-165.
  10. Guardia P, Batlle-Brugal B, Roca AG, Iglesias O, Morales MP, Serna CJ, Labarta A, Batlle X (2007). Surfactant effects in magnetite nanoparticles of controlled size. J Magn Magn Mater 316: E756-E759. Gurunathan S, Han JW, Kim JH (2013). Green chemistry approach for the synthesis of biocompatible graphene. Int J Nanomed 8: 2719-2732.
  11. Knaapen AM, Borm PJA, Albrecht C, Schins RPF (2004). Inhaled particles and lung cancer. Part A: Mechanisms. Int J Cancer 109: 799-809.
  12. Lind K, Kresse M, Debus NP, Muller RH (2002). A novel formulation for superparamagnetic iron oxide (SPIO) particles enhancing MR lymphography: Comparison of physicochemical properties and the in vivo behaviour. J Drug Target 10: 221-230.
  13. Lismont M, Dreesen L (2012). Comparative study of Ag an