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Dergiler / Turkish Journal of Biology / 2018 / Cilt: 42 - Sayı: 6

Peptidomic characterization and bioactivity of Protoiurus kraepelini (Scorpiones: Iuridae) venom

Can ÖZEN
Tuğba SOMAY DOĞAN
Ayşenur BİBER
Selin GEREKÇİ
Hepşen Hazal HÜSNÜGİL
Afife İZBIRAK
Naşit İĞCİ
Sayfa
490–497
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

As the first peptidomic characterization study on P.kraepelini venom, this report lays the foundation for detailed future studies that may lead to the discovery of novel bioactive peptides.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Protoiurus kraepelini is a scorpion species found in parts of Turkey and Greece.
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Temel Bulgular & Veri:The electrophoretic profile of the crude venom showed a protein distribution from 2 to 130 kDa.MALDI-TOF MS analysis of the venom peptide fraction yielded 27 peptides between 1059 and 4623 Da in mass.
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Sonuç & Katkı:As the first peptidomic characterization study on P.kraepelini venom, this report lays the foundation for detailed future studies that may lead to the discovery of novel bioactive peptides.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Protoiurus kraepelini is a scorpion species found in parts of Turkey and Greece. In this study, the peptide profile of its venomwas determined for the first time. The electrophoretic profile of the crude venom showed a protein distribution from 2 to 130 kDa.MALDI-TOF MS analysis of the venom peptide fraction yielded 27 peptides between 1059 and 4623 Da in mass. Several ion channelblocking and antimicrobial peptides were identified by peptide mass fingerprinting analysis. Cytotoxic and antimicrobial effects of thevenom were also demonstrated on Jurkat cells and Escherichia coli, respectively. As the first peptidomic characterization study on P.kraepelini venom, this report lays the foundation for detailed future studies that may lead to the discovery of novel bioactive peptides.

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Bu Makaleye Atıf Yap

ÖZEN, C., DOĞAN, T. S., BİBER, A., GEREKÇİ, S., HÜSNÜGİL, H. H., İZBIRAK, A., İĞCİ, N. (2022). Peptidomic characterization and bioactivity of Protoiurus kraepelini (Scorpiones: Iuridae) venom. Turkish Journal of Biology, Cilt: 42 - Sayı: 6, 490–497. https://ajindex.com/articles/654397

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