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Dergiler / Turkish Journal of Biology / 2020 / Cilt: 44 - Sayı: 6

Oncogenic and tumor suppressor function of MEIS and associated factors

Fatih KOCABAŞ
Birkan GİRGİN
Medine KARADAĞ ALPASLAN
Sayfa
328–355
Yayın Tarihi
2022-11-06
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Herein, MEIS proteins and associated factors in tumorigenesis are discussedwith recent discoveries in addition to how they could be modulated by noncoding RNAs or newly developed small-molecule MEISinhibitors.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:MEIS proteins are historically associated with tumorigenesis, metastasis, and invasion in cancer.
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Temel Bulgular & Veri:MEIS and associated PBXHOX proteins may act as tumor suppressors or oncogenes in different cellular settings.
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Sonuç & Katkı:Herein, MEIS proteins and associated factors in tumorigenesis are discussedwith recent discoveries in addition to how they could be modulated by noncoding RNAs or newly developed small-molecule MEISinhibitors.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

MEIS proteins are historically associated with tumorigenesis, metastasis, and invasion in cancer. MEIS and associated PBXHOX proteins may act as tumor suppressors or oncogenes in different cellular settings. Their expressions tend to be misregulated invarious cancers. Bioinformatic analyses have suggested their upregulation in leukemia/lymphoma, thymoma, pancreas, glioma, andglioblastoma, and downregulation in cervical, uterine, rectum, and colon cancers. However, every cancer type includes, at least, asubtype with high MEIS expression. In addition, studies have highlighted that MEIS proteins and associated factors may function asdiagnostic or therapeutic biomarkers for various diseases. Herein, MEIS proteins and associated factors in tumorigenesis are discussedwith recent discoveries in addition to how they could be modulated by noncoding RNAs or newly developed small-molecule MEISinhibitors.

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Bu Makaleye Atıf Yap

KOCABAŞ, F., GİRGİN, B., ALPASLAN, M. K. (2022). Oncogenic and tumor suppressor function of MEIS and associated factors. Turkish Journal of Biology, Cilt: 44 - Sayı: 6, 328–355. https://ajindex.com/articles/654378

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Kaynakça (13)

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