Dergiler / Türk Onkoloji Dergisi / 2019 / Cilt: 34 - Sayı: 2

Neutrophil/Lymphocyte Ratio and Prognosis in Patients with Non-Metastatic Nasopharyngeal Cancer: A Single-Center Experience

Sayfa
92–99
Yayın Tarihi
2022-11-04
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Statistically significant results were obtained between general survival and sex (p=0.015), KPS(p

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:OBJECTIVENasopharyngeal cancer’s presentation and prognosis are variable.
📊
Temel Bulgular & Veri:The aim of the present study was to investigate clinical outcomes andprognosis, especially the effects of neutrophil/lymphocyte ratio (NLR), of non-metastatic nasopharyngealcarcinoma (NPC) in patients receiving radiotherapy (RT)±chemotherapy (CT) between March 2006 andAugust 2017 in the Eskişehir Osmangazi University Medical Faculty of Radiation Oncology Department.METHODSSixty-two patients with non-metastatic NPC treated with RT±CT were retrospectively evaluated.
💡
Sonuç & Katkı:Statistically significant results were obtained between general survival and sex (p=0.015), KPS(p
🔬Tür:Araştırma Makalesi
📍Kapsam:2006 Verileri
⚙️Değişkenler:Alan Parametreleri

Abstract

OBJECTIVENasopharyngeal cancer’s presentation and prognosis are variable. Even patients with the same clinical stagecan have very different prognoses. The aim of the present study was to investigate clinical outcomes andprognosis, especially the effects of neutrophil/lymphocyte ratio (NLR), of non-metastatic nasopharyngealcarcinoma (NPC) in patients receiving radiotherapy (RT)±chemotherapy (CT) between March 2006 andAugust 2017 in the Eskişehir Osmangazi University Medical Faculty of Radiation Oncology Department.METHODSSixty-two patients with non-metastatic NPC treated with RT±CT were retrospectively evaluated. Patientcharacteristics, such as age, gender, Karnofsky Performance Status (KPS), T phase, N phase, tumor,lymph node, and metastasis phase, histopathologic subgroup, tumor size, NLR, and hemoglobin value,and treatment characteristics, such as concurrent/adjuvant CT status, RT intermission time, and RTtotal time, were investigated.RESULTSMedian overall survival (OS) was 55 (10–134) months, whereas median disease-free survival was 44(6–129) months. The median duration of local control was 48 (6–129) months. Eleven (17.7%) patients developed distant metastases. Distant metastases were detected in 6 (9.7%) patients who had localcontrol. Statistically significant results were obtained between general survival and sex (p=0.015), KPS(p

🔖

Bu Makaleye Atıf Yap

ŞAYLISOY, S., ÖZEN, A., AKÇAY, M., ETİZ, D. (2022). Neutrophil/Lymphocyte Ratio and Prognosis in Patients with Non-Metastatic Nasopharyngeal Cancer: A Single-Center Experience. Türk Onkoloji Dergisi, Cilt: 34 - Sayı: 2, 92–99. https://ajindex.com/articles/639236

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (9)

  1. Chua MLK, Wee JTS, Hui EP, Chan ATC. Nasopharyngeal carcinoma. Lancet 2016;387(10022):1012–24
  2. Lee AW, Ma BB, Ng WT, Chan AT. Management of Nasopharyngeal Carcinoma: Current Practice and Future Perspective. J Clin Oncol 2015;33(29):3356–64
  3. Sun R, Qiu HZ, Mai HQ, Zhang Q, Hong MH, Li YX, et al. Prognostic value and differences of the sixth and seventh editions of the UICC/AJCC staging systems in nasopharyngeal carcinoma. J Cancer Res Clin Oncol 2013;139(2):307–14
  4. Tang LQ, Chen QY, Fan W, Liu H, Zhang L, Guo L, et al. Prospective study of tailoring whole-body dualmodality [18F]fluorodeoxyglucose positron emission tomography/computed tomography with plasma Epstein-Barr virus DNA for detecting distant metastasis in endemic nasopharyngeal carcinoma at initial staging. J Clin Oncol 2013;31(23):2861–9
  5. Chua M, Whee Sze O, Wee J, Soong Y, Lim D, Tan T. Plasma EBV DNA as a Predictive Biomarker in Patients With Endemic Nasopharyngeal Carcinoma Treated With Induction Chemotherapy and Concurrent Chemoradiation Therapy. Int J Radiat Oncol Biol Phys 2014;90(1):S120–S1
  6. Leung SF, Chan KC, Ma BB, Hui EP, Mo F, Chow KC, et al. Plasma Epstein-Barr viral DNA load at midpoint of radiotherapy course predicts outcome in advanced-stage nasopharyngeal carcinoma. Ann Oncol 2014;25(6):1204–8
  7. Shen L, Zhang H, Liang L, Li G, Fan M, Wu Y, et al. Baseline neutrophil-lymphocyte ratio (≥2.8) as a prognostic factor for patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation. Radiat Oncol 2014;9:295
  8. Zhao QT, Yang Y, Xu S, Zhang XP, Wang HE, Zhang H, et al. Prognostic role of neutrophil to lymphocyte ratio in lung cancers: a meta-analysis including 7,054 patients. Onco Targets Ther 2015;8:2731–8
  9. Diakos CI, Charles KA, McMillan DC, Clarke SJ. Cancer-related inflammation and treatment effectiveness. Lancet Oncol 2014;15(11):e493–503. 10.McMillan DC. Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 2009;12(3):223–6. 11.Shalapour S, Karin M. Immunity, inflammation, and cancer: an eternal fight between good and evil. J Clin Invest 2015;125(9):3347–55. 12.Sun W, Zhang L, Luo M, Hu G, Mei Q, Liu D, et al. Pretreatment hematologic markers as prognostic factors in patients with nasopharyngeal carcinoma: Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. Head Neck 2016;38 Suppl 1:E1332–40. 13.Liao LJ, Hsu WL, Wang CT, Lo WC, Cheng PW, Shueng PW, et al. Prognostic impact of