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Dergiler / Turkish Journal of Zoology / 2017 / Cilt: 41 - Sayı: 5

Effect of dual growth factor administration on oxidative markers during acute stage wound healing in rats

Kaan KALTALIOĞLU
Şule COŞKUN CEVHER
Bahar DİNDAR
Sayfa
841–847
Yayın Tarihi
2022-11-05
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This study provides valuableinsights for the development of therapeutic targets that promote wound healing.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Wound healing is a complex process affected by various conditions, including oxidative stress.
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Temel Bulgular & Veri:Woundswere sampled on postsurgery days 3 and 7; samples were assayed for the oxidant markers nitric oxide (NOx) and thiobarbituric acid- reactive substances (TBARs) and the antioxidant markers glutathione (GSH), ascorbic acid (AA), and superoxide dismutase (SOD)activity.
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Sonuç & Katkı:This study provides valuableinsights for the development of therapeutic targets that promote wound healing.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

Wound healing is a complex process affected by various conditions, including oxidative stress. The present study exploredthe time-dependent effects of platelet-derived growth factor (PGDF) and vascular endothelial growth factor (VEGF) administration onoxidative markers during acute stage wound healing. Thirty-six Wistar rats were distributed into three major groups; skin wounds wereinflicted in all groups. The wounds were either left untreated (control group), treated topically with blank chitosan gel (blank chitosangel group), or treated topically with a combination of PDGF and VEGF in chitosan gel (PDGF + VEGF chitosan gel group). Woundswere sampled on postsurgery days 3 and 7; samples were assayed for the oxidant markers nitric oxide (NOx) and thiobarbituric acid- reactive substances (TBARs) and the antioxidant markers glutathione (GSH), ascorbic acid (AA), and superoxide dismutase (SOD)activity. PDGF + VEGF administration increased and decreased NOx levels on days 3 and 7, respectively. PDGF + VEGF administrationlowered TBARs levels, compared with blank chitosan gel administration, on day 7. PDGF + VEGF administration increased GSH levels.These results demonstrate that PDGF + VEGF administration changes oxidative status of wound tissue. This study provides valuableinsights for the development of therapeutic targets that promote wound healing.

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Bu Makaleye Atıf Yap

KALTALIOĞLU, K., CEVHER, Ş. C., DİNDAR, B. (2022). Effect of dual growth factor administration on oxidative markers during acute stage wound healing in rats. Turkish Journal of Zoology, Cilt: 41 - Sayı: 5, 841–847. https://ajindex.com/articles/616191

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Kaynakça (12)

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